Results 31 to 40 of about 264,568 (355)

Empirical roughness coefficients for moderate floods in an open conduit cave: Fullers stream canyon, Culverson Creek Cave System, West Virginia

open access: yesInternational Journal of Speleology, 2022
Open conduit modeling of cave stream floods can yield useful information about water velocities and shear stresses, which can in turn be used to estimate sediment transport capabilities. All such calculations require roughness coefficients for estimating
Lydia Albright, Gregory Springer
doaj   +1 more source

Experimental and numerical studies of the flow structure generated by a submerged sluice gate [PDF]

open access: yes, 2010
Sluice gates are commonly used to control discharge and levels, and to monitor discharge. However discharge formulas perform poorly at large opening and large submergence.
Belaud, Gilles, Cassan, Ludovic
core  

Defensive Medicine and Obstetric Practices [PDF]

open access: yes, 2012
Using data on physician behavior from the 1979–2005 National Hospital Discharge Surveys (NHDS), I estimate the relationship between malpractice pressure, as identified by the adoption of non-economic damage caps and related tort reforms, and certain ...
Frakes, Michael D.
core   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Numerical Study of Discharge Coefficients for Side-Damaged Compartments

open access: yesJournal of Marine Science and Engineering
Accurately evaluating the buoyancy and stability of damaged ships, particularly the flow rate of the water inflow through damaged openings, is of great significance for ship rescue and emergency repair.
Siwen Tian   +3 more
doaj   +1 more source

Meltwater Intrusions Reveal Mechanisms for Rapid Submarine Melt at a Tidewater Glacier [PDF]

open access: yes, 2019
Submarine melting has been implicated as a driver of glacier retreat and sea level rise, but to date melting has been difficult to observe and quantify. As a result, melt rates have been estimated from parameterizations that are largely unconstrained by ...
Amundson, Jason M.   +8 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Discharge coefficients of flat-fan nozzles [PDF]

open access: yes, 2017
The discharge coefficient (Cd) is a measure of how much of the pressure energy of a nozzle is converted into kinetic energy. With the discharge coefficient known, the exit velocity of the liquid sheet from the nozzle can be calculated from the pressure ...
Connell, Robert J.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Experimental Study of Hydraulic Flow of Circular Piano-Key Inlet in Shaft Spillways [PDF]

open access: yesJournal of Rehabilitation in Civil Engineering, 2019
One of the most important conflicts that shaft spillways have to deal with is vortex formation. This phenomenon leads to some unfavorable effects such as vibration in the body of structures, air entrainment and reduced overflow capacity of the spillway ...
Zahra Kashkaki   +3 more
doaj   +1 more source

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