Results 31 to 40 of about 8,035,233 (306)

Development of an Industrial Partial Discharge Calibrator and Its Performance Tests

IEEE Access
In industrial electromechanical manufacturing, ensuring the accuracy of electrical partial discharge measurements is crucial for the reliability and efficiency of electrical power systems.
Ismail Karaman, Ali Ajder, Ismail Nakir
doaj   +1 more source

Estimating River Discharge With Swath Altimetry: A Proof of Concept Using AirSWOT Observations

Geophysical Research Letters, 2019
The forthcoming Surface Water and Ocean Topography (SWOT) satellite mission will provide global measurements of the free surface of large rivers, providing new opportunities for remote sensing‐derived estimates of river discharge in gaged and ungaged ...
S. Tuozzolo, G. Lind, B. Overstreet, J. Mangano, M. Fonstad, M. Hagemann, R. P. M. Frasson, K. Larnier, P.‐A. Garambois, J. Monnier, M. Durand   +10 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Siting Considerations for Satellite Observation of River Discharge

Water Resources Research
With growing global capability for satellite measurement of river discharge (flow) comes a need to understand and reduce error in satellite‐based discharge measurements. Satellite‐based discharge estimates are based on measurements of water surface width,
Jack Eggleston, Chris Mason, Dave Bjerklie, Mike Durand, Rob Dudley, Merritt Harlan   +5 more
doaj   +1 more source

How Does the Unique Space‐Time Sampling of the SWOT Mission Influence River Discharge Series Characteristics?

Geophysical Research Letters, 2019
The Surface Water and Ocean Topography (SWOT) satellite mission will, for the first time, provide simultaneous, high‐resolution measurements of water surface elevation and extent.
Cassandra Nickles, Edward Beighley, Yuanhao Zhao, Michael Durand, Cedric David, Hyongki Lee   +5 more
doaj   +1 more source

Run-off modelling in an Arctic unglaciated catchment (Fuglebekken, Spitsbergen)

Annals of Glaciology, 2017
The goal of this study is to test applicability of the conceptual catchment run-off HBV model to simulate discharge in small non-glaciated Arctic catchment. Within two ablation seasons, 2014 and 2015, in the Fuglebekken catchment (Spitsbergen, Svalbard),
Tomasz Wawrzyniak, Marzena Osuch, Adam Nawrot, Jaroslaw Jan Napiorkowski   +3 more
doaj   +1 more source

Technical Note: How image processing facilitates the rising bubble technique for discharge measurement [PDF]

Hydrology and Earth System Sciences, 2012
In this article, we rehabilitate the integrating rising bubble technique as an effective means of obtaining discharge measurements. Since Sargent (1981, 1982a), the technique has not been applied widely, mainly as a result of practical difficulties.
K. P. Hilgersom, W. M. J. Luxemburg
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

MODELING OF ONE DIMENSIONAL FLOW OVER SEMICIRCLE CRESTED WEIR PROFILE USING (HEC-RAS) PROGRAM

Diyala Journal of Engineering Sciences, 2017
A semicircle crest profile extending across full width of laboratory channel (suppressed) provides measurements of discharge – head under free flow condition.
Thabet mohammed abdulatif
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source