Results 81 to 90 of about 32,488 (260)
Advanced Science, EarlyView.In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li +15 more
wiley +1 more source
Administrative-Delict Legal Relations and Their Features
Сибирское юридическое обозрение, 2020 Involvement in administrative, disciplinary, material types of responsibility in administrative law is classified as an administrative coercion. The Author proposes to expand the range of administrative-tort legal relations, including not only legal ...
P. E. Spiridonov
doaj
Advanced Science, EarlyView.This study clarifies the genetic patterns of paternal lineages across East Asia and Mainland Southeast Asia. Han populations are relatively homogeneous, whereas southern ethnolinguistic minorities display regional structures. Shared Y‐chromosome lineages indicate Neolithic expansions and extensive north‐south gene flow, supporting demic diffusion ...
Yunhui Liu +15 more
wiley +1 more source
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
DISCIPLINARY RESPONSABILITY OF TEACHERS IN HIGHER EDUCATION
Agora International Journal of Juridical Sciences, 2013 The regulations contained in Law no.1/2011, complete the common regulations thatcan be found the Labor Code. This way, the teachers in university education are going to bepenalized disciplinarily, as much for the infringement of the common law directives (LaborCode), as for the behavior rules violation that prejudice the Education System interest and ...
openaire +2 more sources
Advanced Science, EarlyView.This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang +12 more
wiley +1 more source
Публічне управління та регіональний розвитокThe article outlines the theoretical aspects of prosecution for corruption or corruption-related offenses and analyzes the national court practice of consideration of relevant cases.
Anastasiia Shulha, Volodymyr Kalytaev
doaj +1 more source
Advanced Science, EarlyView.The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang +12 more
wiley +1 more source
Legal liability of servicemen for improper performance of duties during physical fitness testing
Bulletin of Kharkiv National University of Internal AffairsThe article examines the theoretical foundations and practical implementation of the legal responsibility of military personnel for improper performance of duties during physical fitness testing.
S. M. Ivashchenko +2 more
doaj +1 more source