Results 151 to 160 of about 852,357 (308)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Market Indicators, Bank Fragility, and Indirect Market Discipline [PDF]
We examine whether two commonly used indicators of bank fragility, the subordinated debt spread and KMV’s distance to default, yield signals in line with supervisors’ interests.
Giuseppe Vulpes +2 more
core
Beyond the undergraduate experience: Pre-arrival expectations of postgraduate taught students at a UK university. [PDF]
PLoS OneHibbs A, Hayman R, Grenade D, Polman R.
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Influencing factors of nursing discipline construction in a Chinese tertiary hospital: a qualitative study. [PDF]
Front Med (Lausanne)Lu X, Zhu H, Li M.
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Discipline diversity and agency : pedagogic practice and dispositions to learning
, 2010 What, then, makes discipline good? .. .is not discipline-all discipline-essentially a restraint, a limitation imposed on man's behaviour? If life is good, how can it be good to bridle it, to constrain it, to impose limits that it cannot overcome ...
Watkins, Megan (R10473)
core
Teacher Discipline Intensity and Adolescents' Mental Health Problems: A Moderated Moderation Effect Based on CEPS 2013-2014 Survey Data. [PDF]
Behav Sci (Basel)Qi C, Zhang Z.
europepmc +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source