Results 11 to 20 of about 591,464 (366)

Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: a global systematic review and meta-analysis.

The Lancet HIV, 2022
BACKGROUND Poor adherence to oral HIV pre-exposure prophylaxis (PrEP) diminishes its clinical and public health benefits. This study synthesises evidence regarding discontinuation, adherence, and reinitiation of PrEP among geographically diverse PrEP ...
Jing Zhang, Chunyan Li, Junjie Xu, Zhili Hu, S. Rutstein, J. Tucker, J. Ong, Yongjun Jiang, W. Geng, S. Wright, M. Cohen, H. Shang, W. Tang   +12 more
semanticscholar   +1 more source

Discontinuous neural networks and discontinuity learning

Journal of Computational and Applied Mathematics, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Della Santa, Francesco, Pieraccini, Sandra   +1 more
openaire   +1 more source

Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial

The Lancet Respiratory Medicine, 2021
Background Biological considerations suggest that renin–angiotensin system inhibitors might influence the severity of COVID-19. We aimed to evaluate whether continuing versus discontinuing renin–angiotensin system inhibitors (angiotensin-converting ...
Jordana B. Cohen, T. Hanff, Preethi William, N. Sweitzer, Nelson R Rosado-Santander, Carola Medina, Juan E Rodriguez-Mori, N. Renna, T. Chang, V. Corrales-Medina, J. Andrade-Villanueva, Alejandro Barbagelata, Roberto Cristodulo-Cortez, Omar A Díaz-Cucho, J. Spaak, C. Alfonso, Renzo Valdivia-Vega, Mirko Villavicencio-Carranza, Ricardo J Ayala-García, Carlos A Castro-Callirgos, L. González-Hernández, Eduardo F Bernales-Salas, Johanna C Coacalla-Guerra, Cynthia D Salinas-Herrera, L. Nicolosi, Mauro Basconcel, J. B. Byrd, Tiffany Sharkoski, Luis E Bendezú-Huasasquiche, J. Chittams, Daniel L. Edmonston, C. Vasquez, J. Chirinos   +32 more
semanticscholar   +1 more source

Denosumab Discontinuation and the Rebound Phenomenon: A Narrative Review

Journal of Clinical Medicine, 2021
Denosumab is a potent antiresorptive agent that substantially increases bone mineral density and reduces fracture rates at all skeletal sites for as long as it is administered.
A. Anastasilakis, P. Makras, M. Yavropoulou, G. Tabacco, A. Naciu, A. Palermo   +5 more
semanticscholar   +1 more source

Maintenance or Discontinuation of Antidepressants in Primary Care.

New England Journal of Medicine, 2021
BACKGROUND Patients with depression who are treated in primary care practices may receive antidepressants for prolonged periods. Data are limited on the effects of maintaining or discontinuing antidepressant therapy in this setting.
Gemma Lewis, L. Marston, L. Duffy, N. Freemantle, S. Gilbody, R. Hunter, T. Kendrick, D. Kessler, D. Mangin, M. King, P. Lanham, M. Moore, I. Nazareth, N. Wiles, Faye Bacon, Molly Bird, S. Brabyn, A. Burns, C. Clarke, A. Hunt, J. Pervin, G. Lewis   +21 more
semanticscholar   +1 more source

Ventilator Weaning and Discontinuation Practices for Critically Ill Patients.

Journal of the American Medical Association (JAMA), 2021
Importance Although most critically ill patients receive invasive mechanical ventilation (IMV), few studies have characterized how IMV is discontinued in practice.
K. Burns, Leena Rizvi, D. Cook, G. Lebovic, P. Dodek, J. Villar, Arthur S Slutsky, Andrew T. Jones, F. Kapadia, D. Gattas, S. Epstein, P. Pelosi, K. Kefala, M. Meade   +13 more
semanticscholar   +1 more source

RANDOMIZED, OPEN-LABEL NON-INFERIORITY TRIALS EVALUATING DISCONTINUATION VERSUS CONTINUATION OF HYPERTONIC SALINE OR DORNASE ALFA IN MODULATOR TREATED PEOPLE WITH CYSTIC FIBROSIS: RESULTS FROM THE SIMPLIFY STUDY

The Lancet Respiratory Medicine, 2022
SUMMARY Background: Reducing treatment burden is a priority for people with cystic fibrosis (CF) whose health has benefited from using newer modulators that substantially increase cystic fibrosis transmembrane conductance regulator (CFTR) protein ...
N. Mayer-Hamblett, F. Ratjen, R. Russell, S. Donaldson, K. Riekert, G. Sawicki, K. Odem-Davis, Julia K Young, D. Rosenbluth, J. Taylor-Cousar, C. Goss, G. Retsch-Bogart, J. Clancy, A. Genatossio, B. O’Sullivan, A. Berlinski, S. Millard, G. Omlor, Colby A. Wyatt, K. Moffett, D. Nichols, A. Gifford, M. Kloster, K. Weaver, C. Chapdu, Jing Xie, M. Skalland, Melita Romasco, Sonya L Heltshe, N. Simon, J. Vandalfsen, A. Mead, Rachael Buckingham, K. Seidel, Nikita Midamba, Laurel Couture, Brooke Zappone Case, Wendy Au, E. Rockers, D. Cooke, Amber Olander, I. Bondick, M. Johnson, Lisya VanHousen, B. Nicholson, Michelle Parrish, D. Roberts, J. Head, J. Carey, Lindsay J. Caverly, J. Dangerfield, Rachel W. Linnemann, J. Fullmer, Chelsea Roman, P. Mogayzel, D. Reyes, Amy Harmala, J. Lysinger, Jonathan M. Bergeron, I. Virella-Lowell, P. Brown, L. Godusevic, Alicia Casey, Laure Paquette, T. Lahiri, J. Sweet, S. Donaldson, Joshua C Harris, Shelia Parnell, S. Szentpetery, D. Froh, E. Tharrington, Manu Jain, R. Nelson, Sharon Kadon, Gary McPhail, Kimberly A McBennett, Tia Rone, E. Dasenbrook, David Weaver, T. Johnson, K. McCoy, R. Jain, M. Mcleod, M. Klosterman, P. Sharma, Amy Jones, Gary Mueller, R. Janney, J. Taylor-Cousar, M. Cross, J. Hoppe, James Cahill, Z. Mukadam, Jill Finto, K. Schultz, Silvia Delgado Villalta, A. Smith, S. Millard, T. Symington, G. Graff, D. Kitch, D. Sanders, M. Thompson, Tahuanty A. Peña, Mary E. Teresi, Jennifer Gafford, D. Schaeffer, J. Mermis, Lorne Scott, Hugo Escobar, Kristen Williams, Dana B. Dorman, B. O'sullivan, Ryan Bethay, Zoran Danov, Katherine Turbeville, J. Johannes, Angelina Rodriguez, B. Marra, R. Zanni, Robert W Morton, Terri Simeon, Andrew Braun, Nicole Dondlinger, J. Biller, E. Hubertz, Nicholas Antos, Laura Roth, J. Billings, Catherine Larson, P. Balaji, J. McNamara, T. Clark, Rebecca Griffith, N. Martinez, Sabiha R. Hussain, Halina Malveaux, Marie Egan, Catalina Guzmán, J. DeCelie-Germana, Susan Galvin, A. Savant, N. Falgout, Patricia A. Walker, T. Demarco, E. DiMango, M. Ycaza, Julie Ballo, Pornchai Tirakitsoontorn, D. Layish, Desiree Serr, Floyd Livingston, Sherry Wooldridge, C. Milla, J. Spano, Rebecca Davis, O. Elidemir, S. Chittivelu, A. Scott, Sarah Alam, D. Dorgan, Matthew Butoryak, Daniel Weiner, Harmony Renna, Colby A. Wyatt, Brendan D Klein, A. Stone, Margaret K. Lessard, M. Schechter, Barbara Johnson, Steve Scofield, T. Liou, J. Vroom, K. Akong, M. Gil, L. Betancourt, Jonathan A. Singer, N. Ly, C. Moreno, M. Aitken, T. Gambol, R. Gibson, Allison Lambert, J. Milton, Sarah Smith, Deanna M. Green, D. Hodge, C. Fortner, M. Forell, R. Karlnoski, K. Patel, Cori Daines, Elizabeth Ryan, R. Amaro-Galvez, Elizabeth Dohanich, A. Lennox, Z. Messer, Holly Hanes, Kay Powell, Deepika Polineni   +200 more
semanticscholar   +1 more source

Fracture risk and management of discontinuation of denosumab therapy: a systematic review and position statement by ECTS.

Journal of Clinical Endocrinology and Metabolism, 2020
CONTEXT Denosumab discontinuation is characterized by an increase in bone turnover overriding pre-treatment status, a rapid bone loss in the majority and multiple vertebral fractures (VFx) in some patients.
E. Tsourdi, M. Zillikens, C. Meier, J. Body, Elena Gonzalez Rodriguez, A. Anastasilakis, Bo Abrahamsen, Bo Abrahamsen, E. McCloskey, L. Hofbauer, N. Guañabens, B. Obermayer-Pietsch, S. Ralston, R. Eastell, J. Pepe, A. Palermo, B. Langdahl   +16 more
semanticscholar   +1 more source

THE DISCONTINUITY PROBLEM

The Journal of Symbolic Logic, 2022
AbstractMatthias Schröder has asked the question whether there is a weakest discontinuous problem in the topological version of the Weihrauch lattice. Such a problem can be considered as the weakest unsolvable problem. We introduce the discontinuity problem, and we show that it is reducible exactly to the effectively discontinuous problems, defined in ...
openaire   +2 more sources

Understanding Study Drug Discontinuation Through EUCLID [PDF]

, 2022
Introduction: Disparities in the care and outcomes of peripheral artery disease (PAD) have been well-established. In part this is due to disparities in enrollment of PAD trial cohorts.
Patel, Manesh R.,, Mahaffey, Kenneth, Katona, Brian G.,, Jones, W. Schuyler, E. Hope Weissler, W. Schuyler Jones, Fowkes, F. Gerry R., Hillary Mulder, Iris Baumgartner, Mahaffey, Kenneth,, Fowkes, F. Gerry R.,, Patel, Manesh R., Mulder, Hillary, Bonaca, Marc, Baumgartner, Iris,, Blomster, Juuso,, Weissler, E. Hope,, Frank W. Rockhold, Norgren, Lars, Rockhold, Frank W., Jones, W. Schuyler,, Rockhold, Frank W, Baumgartner, Iris, Katona, Brian G, Blomster, Juuso, Juuso Blomster, Brian G. Katona, Kenneth Mahaffey, Mulder, Hillary,, Weissler, E Hope, Lars Norgren, Patel, Manesh R, F. Gerry R. Fowkes, Jones, W Schuyler, Katona, Brian G., Marc Bonaca, Rockhold, Frank W.,, Manesh R. Patel, Bonaca, Marc,, Fowkes, F Gerry R, Weissler, E. Hope, Norgren, Lars,   +41 more
core   +1 more source