Results 41 to 50 of about 591,464 (366)

Safety of immune checkpoint inhibitor rechallenge after discontinuation for grade ≥2 immune-related adverse events in patients with cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Safety of rechallenge of immune checkpoint inhibitor (ICI) after grade ≥2 immune-related adverse events (irAEs) leading to ICI discontinuation remains unclear.
M. Allouchery, Thomas Lombard, Mickaël Martin, Franck Rouby, M. Sassier, Célia Bertin, Marina Atzenhoffer, G. Miremont-Salamé, M. Pérault-Pochat, M. Puyade   +9 more
semanticscholar   +1 more source

Explosive synchronization is discontinuous [PDF]

Physical Review E, 2015
Spontaneous explosive is an abrupt transition to collective behavior taking place in heterogeneous networks when the frequencies of the nodes are positively correlated to the node degree. This explosive transition was conjectured to be discontinuous. Indeed, numerical investigations reveal a hysteresis behavior associated with the transition.
Vlasov, Vladimir, Zou, Yong, Pereira, Tiago   +2 more
openaire   +3 more sources

Epistaxis Versus Nonepistaxis Bleeding in Anticoagulated Patients With Atrial Fibrillation: Results From the ENGAGE AF‐TIMI 48 Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Epistaxis is common with antithrombotic therapy and is often troublesome to patients, yet its frequency, severity, and outcomes are poorly characterized.
Robert S. Semco, Regan W. Bergmark, Sabina A. Murphy, Abby L. Cange, Martin Unverdorben, Cathy Z. L. Chen, Christian T. Ruff, Elliott M. Antman, Robert P. Giugliano, Brian A. Bergmark   +9 more
doaj   +1 more source

Real-World Adherence and Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists Therapy in Type 2 Diabetes Mellitus Patients in the United States

Patient Preference and Adherence, 2020
Aim To assess adherence and discontinuation of injectable glucagon-like peptide-1 receptor agonists (GLP-1 RA) at 12 and 24 months among adult type 2 diabetes mellitus (T2DM) patients in the United States initiating GLP-1 RA using the administrative ...
Tracey Weiss, R. Carr, Sampriti Pal, Lingfeng Yang, B. Sawhney, R. Boggs, S. Rajpathak, K. Iglay   +7 more
semanticscholar   +1 more source

Adverse events after antipsychotic discontinuation: an individual participant data meta-analysis.

, 2022
BACKGROUND Adverse events can occur after antipsychotic discontinuation but evidence from antipsychotic drug trials is scarce. We aimed to estimate the occurrence of adverse events after discontinuing antipsychotics.
Stefan Leucht, Alkomiet Hasan, Luka Loncar, Leucht, Stefan, Hasan, Alkomiet, Brandt, Lasse, Spyridon Siafis, Orestis Efthimiou, Heinz, Andreas, Lasse Brandt, Bermpohl, Felix, Gutwinski, Stefan, Siafis, Spyridon, Konrad Neumann, Efthimiou, Orestis, Schneider-Thoma, Johannes, Neumann, Konrad, Felix Bermpohl, Andreas Heinz, Stefan Gutwinski, Loncar, Luka, Johannes Schneider-Thoma   +21 more
core   +1 more source

Discontinuation versus continuation of renin–angiotensin system inhibitors in chronic kidney disease stage 3–5 patients: a systematic review and meta-analysis

Frontiers in Pharmacology
BackgroundRenin-angiotensin system inhibitors (RASi), comprising angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) are known for cardio- and renoprotection.
I-Wen Chen, I-Wen Chen, Yi-Hsuan Lin, Yi-Hsuan Lin, Vin-Cent Wu, Jui-Yi Chen, Jui-Yi Chen, Ming-Hsien Wu, Ming-Hsien Wu, Ming-Hsien Wu   +9 more
doaj   +1 more source

Safety of Dual‐Antiplatelet Therapy After Myocardial Infarction Among Patients With Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Although recommended in the guidelines, the safety of chronic P2Y12 inhibitor therapy in patients with chronic kidney disease (CKD) after an acute myocardial infarction (MI) is not well studied. Methods and Results The TRANSLATE‐ACS (Treatment
Jennifer A. Rymer, Lisa A. Kaltenbach, Jacob A. Doll, John C. Messenger, Eric D. Peterson, Tracy Y. Wang   +5 more
doaj   +1 more source

Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma.

Annals of Oncology, 2019
BACKGROUND PD-1 blocking monoclonal antibodies improve the overall survival of patients with advanced melanoma but the optimal duration of treatment has not been established.
Y. Jansen, E. A. Rozeman, R. Mason, S. Goldinger, M. G. Foppen, L. Hoejberg, Henrik Schmidt, J. V. Thienen, J. Haanen, L. Tiainen, I. Svane, S. Mäkelä, Tina Seremet, A. Arance, Reinhard Dummer, L. Bastholt, M. Nyakas, O. Straume, A. Menzies, A. Menzies, Georgina V. Long, Georgina V. Long, V. Atkinson, C. U. Blank, B. Neyns   +24 more
semanticscholar   +1 more source

DISCONTINUITY OF KNOWLEGDE

Beykent Üniversitesi Sosyal Bilimler Dergisi, 2017
M. Foucault and T. Kuhn concerned with the discontinuity of discourse in the sciences and social disciplines. In 1960s Kuhn stated that the natural science reflects basically a sequence of paradigm changes. In 1970s Foucault claimed a form of discourse about the growth of scientific knowledge in a range of human and medical sciences.
openaire   +3 more sources

Discontinuities without discontinuity: The Weakly-enforced Slip Method [PDF]

Computer Methods in Applied Mechanics and Engineering, 2014
Submitted for publication in ...
Zwieten, van, G.J., Brummelen, van, E.H., Zee, van der, K.G., Gutiérrez, M.A., Hanssen, R.F.   +4 more
openaire   +4 more sources