Results 111 to 120 of about 90,682 (248)

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa‐I Trial

Annals of Neurology, EarlyView.
In this post hoc analysis of the ANNEXa‐I trial (n = 434), we evaluated non‐contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) –associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12.5 mL or ≥ 35% increase in hematoma volume) occurred in 31.8 ...
Koji Tanaka, Umberto Pensato, Mohamed Alshamrani, Aristeidis H. Katsanos, Pargol Balali, Sucharita Ray, Scott E. Kasner, Jan Beyer‐Westendorf, Danilo Toni, David J. Seiffge, Carlos Molina, David Tanne, Anna Członkowska, Arne G. Lindgren, Daniel Bereczki, Else C. Sandset, Georgios Tsivgoulis, Hanne Christensen, Jonathan M. Coutinho, Peter Verhamme, Pierre Amarenco, Robin Lemmens, Roland Veltkamp, Saskia Middeldorp, Thompson Robinson, Truman J. Milling, Wilfried Lang, Vitor Tedium‐Cruz, Mark Crowther, Lizhen Xu, Mikael Knutsson, Per Ladenvall, John W. Eikelboom, Mukul Sharma, Ashkan Shoamanesh, Andrew M. Demchuk   +35 more
wiley   +1 more source

Research on Heat Transfer Enhancement of Spiral Grooved Tube Heat Exchangers Based on CFD and Artificial Intelligence

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Driven by the energy crisis and carbon neutrality goals, high‐efficiency heat exchange equipment has become a core demand in the industrial sector. The spiral grooved double‐pipe heat exchanger exhibits significant heat transfer enhancement advantages, yet it requires balancing heat transfer efficiency and pressure loss.
Yueyun Yang, Wei Li, Xiuzhi Xi, Neng Gao
wiley   +1 more source

Editorial Commentary: Contact Is Not Containment: In High‐Grade Trochlear Dysplasia, the Patellotrochlear Index Quantifies Cartilage Overlap in the Absence of Osseous Constraint

Arthroscopy, EarlyView.
Abstract Patella alta remains among the most critical anatomical risk factors for recurrent patellofemoral instability and failure of patellar stabilization surgery. The Caton‐Deschamps index references the patella to the tibia by measuring the position of the patella relative to the anterosuperior margin of the tibial plateau.
Dustin J. Kress, Toufic R. Jildeh
wiley   +1 more source

Lung Ultrasound for the Detection of Radiologic Progression of Interstitial Lung Abnormalities in Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Interstitial lung disease (ILD) is an important extra‐articular manifestation of rheumatoid arthritis (RA) associated with high mortality and morbidity. Lung ultrasonography (LUS) has recently emerged as a possible screening tool. We assessed the role of LUS in monitoring radiologic progression and the development of new interstitial lung ...
Marie Vermant, Valerie Van Ballaer, Joseph Jacob, Tine Follet, Ryoko Egashira, Kenny Anseele, Heleen Cypers, Laurens J. De Sadeleer, Nico De Crem, Tinne Goos, Barbara Neerinckx, Veerle Taelman, Nathalie Veyt, Alexandros Kalkanis, Patrick Verschueren, Wim A. Wuyts   +15 more
wiley   +1 more source

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

Arthritis &Rheumatology, Accepted Article.
Objectives Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

Expert Perspective: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, Accepted Article.
Treat‐to‐target (T2T) has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal T2T framework for adult IIM has not yet been established.
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Intra- and intertumoral discordance of Claudin-18.2: a systematic review and meta-analysis. [PDF]

ESMO Gastrointest Oncol
Vanneste TLM, Sánchez DIR, van der Mierden S, Vollebergh MA, Kodach LL, van Sandick J, Beets-Tan RGH, Snaebjornsson P, Bodalal Z.   +8 more
europepmc   +1 more source

Treatment‐driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B‐cell therapy in Sjögren's disease

Arthritis &Rheumatology, Accepted Article.
Objective To characterise whole‐blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non‐response. Methods Whole‐blood RNA sequencing was performed at baseline and week‐24 in participants (n=43) from a
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

The mythical concept and untoward consequences of a diagnosis of dysplastic nevus: an overdue tribute to A. Bernard Ackerman, MD

Dermatology Practical & Conceptual, 2015
Robert M. Hurwitz, Morton E. Tavel
doaj   +1 more source