Results 91 to 100 of about 1,570,418 (352)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On temporality in discourse annotation: Theoretical and practical considerations

open access: yes, 2017
Temporal information is one of the prominent features that determine the coherence in a discourse. That is why we need an adequate way to deal with this type of information during discourse annotation.
Hoek, Jet   +5 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Action Schemas Can Account for Prototypical and Non-Prototypical Palm-Up Open Hand Gestures

open access: yesLanguages
Palm-Up Open Hand (PUOH) gestures are often treated in the literature as one type that can perform different functions. However, the focus on the palm orientation and handshape has led to a puzzle in terms of explaining the several functions that these ...
Alan Cienki   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Detecting patterns of change in the development of the Mandarin dative alternation: from attraction to differentiation and the reversal

open access: yesCognitive Linguistics
The Mandarin dative alternation encompasses four constructions whose changing functions and driving forces of change have not been systematically addressed.
Liu Meili, Li Yi
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

In the Antechamber of a New Global Bipolarity [PDF]

open access: yesRomanian Journal of European Affairs, 2016
This paper investigates the shifts in the international balance of power, that we attribute both to the weakening status of the US globally and to the rise of regional powers.
Paul Dobrescu, Mălina Ciocea
doaj  

Narrative as a term in narratology and music theory

open access: yesRasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2018
The paper compares the term narrative as it is used by narratologists, and as it is used by music scholars, to establish whether these two disciplines use the term in the same way, or as two homonyms.
Smiljana Narančić Kovač, Iva Kovač
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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