Results 71 to 80 of about 369,838 (308)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

ENGLISH TASK TO DEVELOP THE STUDENTS’ COMMUNICATIVE COMPETENCE: A STUDY OF EDUKATIF WORK BOOK FOR JUNIOR HIGH SCHOOL STUDENTS

open access: yesJurnal Penelitian Humaniora, 2013
This study is mainly intended to find out the extent to which tasks in English work books are designed to develop the students’ communicative competence.
Dyah Rohma Wati   +2 more
doaj  

Tłumaczenie jako świadczenie usług tłumaczeniowych?

open access: yesMiędzy Oryginałem a Przekładem, 2013
Translation as provision of translation services? At the crossroads between enhancing professional realism and serving the needs of the industry in translator education The paper seeks to analyze the current discourse in the field of translator ...
Joanna Dybiec‑Gajer
doaj   +1 more source

Interlocutors-Related and Hearer-Specific Causes of Misunderstanding: Processing Strategy, Confirmation Bias and Weak Vigilance [PDF]

open access: yes, 2017
Noises, similarities between words, slips of the tongue, ambiguities, wrong or false beliefs, lexical deficits, inappropriate inferences, cognitive overload, non-shared knowledge, topic organisation or focusing problems, among others, may cause ...
Cruz, Manuel Padilla
core   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Registered Nurses’ Patient Education in Everyday Primary Care Practice

open access: yesGlobal Qualitative Nursing Research, 2015
Nurses’ patient education is important for building patients’ knowledge, understanding, and preparedness for self-management. The aim of this study was to explore the conditions for nurses’ patient education work by focusing on managers’ discourses about
Anne-Louise Bergh   +3 more
doaj   +1 more source

Communicative Competence in Professional Discourse [PDF]

open access: yesLinguistics and Literature Studies, 2015
Steadily increasing global connectivity, integration and interdependence affect workplace relations, which have to be adapted to the new reality. Global workers need to know how to operate in new, often challenging environment, how to understand cultural diversity and ethical issues. Communicative competence, a skill that is top-ranked by employers, is
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Creative Writing Activities for Exploring Seventh Graders’ Written discourse Competence

open access: yesEnletawa Journal, 2013
This project proposes Creative Writing as a pedagogical strategy to  improve 7th graders’ written discourse competence. Creative Writing is described as a chance to experiment freely with language, and it helps to develop an efficient composing process ...
Cristina Hurtado Pérez
doaj   +1 more source

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