Results 81 to 90 of about 369,838 (308)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
DISCURSIVE REPRESENTATIONS OF «DIGITAL GENERATION» AND A NEW EDUCATION PARADIGM
Sovremennye Issledovaniâ Socialʹnyh Problem, 2018 The paper analyzes the tendency to describe the relationship between subjects of the educational process in terms of “digital generation”, “digital natives” and “digital immigrants”. Since the early 2000s the tendency has stably functioned in the Russian
Svetlana Alexandrovna Sheypak
doaj +1 more source
Beyond foreign language writing instruction: The need for literacy pedagogy [PDF]
, 2011 The situation we have found ourselves in after 1989 has all the signs of a literacy crisis. As academic teachers, we find the academic literacy skills of many our students below our expectations. Yet, we must not exclude such students, but admit them and
Zalewski, Jan
core
Trilingual conversations: a window into multicompetence [PDF]
, 2007 A recurrent theme in the literature on trilingual language use is the question of whether there is a specific “trilingual competence.” In this paper we consider this question in the light of codeswitching patterns in two dyadic trilingual conversations ...
Baetens Beardsmore, H. +12 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Sign Systems Studies, 2001 A central claim of biosemiotics is the ascription of semiotic competence to nonhumans. For strange historical reasons, this claim has been quite controversial in much of standard biological discourse.
Andreas Roepstorff
doaj +1 more source
Linguistic incompetence: giving an account of researching multilingually [PDF]
, 2013 This paper considers the place of linguistic competence and incompetence in the context of researching multilingually. It offers a critique of the concept of competence and explores the performative dimensions of multilingual research and its narration ...
Barnett R. +16 more
core +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
THE NON-ENGLISH LECTURERS’ READING COMPETENCE IN READING ENGLISH TEXT AT HIGHER EDUCATION IN CENTRAL JAVA [PDF]
, 2016 Nowadays, the government offers a lot of scholarships to non-English lecturers to study abroad. However, only a few that could get the scholarship due to their inability to communicate in English or to comprehend English texts. In this paper, therefore,
Sophia B , Th. Cicik +2 more
core
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source