Results 161 to 170 of about 6,919,055 (340)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Models simulation and interoperability using MDA and HLA

, 2006
In the manufacturing context, there have been numerous efforts to use modeling and simulation tools and techniques to improve manufacturing efficiency over the last four decades. While an increasing number of manufacturing system decisions are being made
Haouzi, Hind El
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Extraterritorial militarism: emigrants as soldiers in Israel

Comparative Migration Studies
Militarism is a discourse that glorifies soldiers and treats military service as a key component of full citizenship. This article contends that states can project militaristic discourse onto citizens living outside their territory, thus creating an ...
Jonathan Grossman
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

"Text" and "discourse" as "context"

, 2009
In recent proposals for the crucial internal structure of the framing Contextual Component within Functional Discourse Grammar (Hengeveld & Mackenzie 2006,2008) -- for example by Rijkhoff (2008:88-97) and Connolly (2007) --, what is here called text is considered as equivalent to discourse within an account of the NP (Rijkhoff) or of context (Connolly).
openaire   +2 more sources

TWO-COMPONENT ATTRIBUTIVE CONSTRUCTIONS IN JUDICIAL PROCEDURE DISCOURSE

Тrаnscarpathian Philological Studies, 2022
T.I. Borisenko, M.V. Tsinova, E.B. Grodska   +2 more
openaire   +1 more source

Combining Expression and Content in Domains for Dialog Managers

, 1998
We present work in progress on abstracting dialog managers from their domain in order to implement a dialog manager development tool which takes (among other data) a domain description as input and delivers a new dialog manager for the described domain ...
Goerz, Guenther, Ludwig, Bernd, Niemann, Heinrich   +2 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source