Results 1 to 10 of about 169,296 (215)
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
Cell Reports, 2023 We thank Alex Berndt and ESRF ID29 beamline scientist Christoph Müller-Dieckmann for assistance with X-ray diffraction data collection.Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 ...
Harish Ranga-Prasad, John E Burke
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International Journal of Molecular Sciences, 2023 Cyclophosphamide causes side effects in cancer patients, including hepatotoxicity. Probiotics have recently emerged as potential approaches for the administration of many diseases.
Shanji Liu, Hengyi Xu, Xu Hengyi
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Science Advances, 2021 The structure of class IB PI3K (p110γ-p101) reveals mechanism of GPCR activation and differences from class IA PI3Ks.
Manoj K Rathinaswamy +2 more
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Bioengineered, 2022 Dysfunction of intestinal epithelial cells (IECs) leads to intestinal epithelial barrier damage and critically involves in the pathogenesis and development of ulcerative colitis (UC).
Jihong Zhong (12314988) +3 more
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International Journal of NanomedicineLixin Xie,1,* Lihua Feng,1,* Xiaomin Tang,1 Yunping Xu,1 Hengyi Xu,2 Yang Liu1 1Department of Pediatrics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 2State Key Laboratory of
Liu Y, Feng L, Xie L, Xu H, Tang X, Xu Y
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The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101
Cell, 1997 Two highly similar, PtdIns(4,5)P2-selective, Gβγ-activated PI3Ks were purified from pig neutrophil cytosol. Both were heterodimers, were composed of a 101 kDa protein and either a 120 kDa or a 117 kDa catalytic subunit, and were activated greater than ...
Alicia Eguinoa +2 more
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The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ
Biochemical Journal, 2012 G-protein-regulated PI3Kγ (phosphoinositide 3-kinase γ) plays a crucial role in inflammatory and allergic processes. PI3Kγ, a dimeric protein formed by the non-catalytic p101 and catalytic p110γ subunits, is stimulated by receptor-released Gβγ complexes.
Aliaksei Shymanets +2 more
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Science Signaling, 2020 PI3Kγ complexes containing p101 or p84 are directly activated by Gβγ in a GPCR-dependent manner in neutrophils. How to activate PI3Kγ in neutrophils A critical effector of GPCRs in neutrophils is PI3Kγ, but how the two PI3Kγ complexes are activated by ...
Natalie K Rynkiewicz +2 more
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Educazione Linguistica Language Education, 2023 This work discusses didactic strategies - based on the Communicative and Competency – based Approach – and the use of authentic materials to promote the Meaningful Learning of Portuguese as Foreign Language in early childhood to stimulate the ...
Rossi, Maria Antonietta
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Autoimmunity, 2023 LncRNA OIP5-AS1 has a common gene imbalance in various cancers and tumours, which plays an important role in regulating its biological function. However, there are few studies on lncRNA OIP5-AS1 in rheumatoid arthritis (RA).
Yuan‐Bo Sun +6 more
semanticscholar +1 more source