Results 271 to 280 of about 6,919,055 (340)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Explainable AI-enabled adaptive fuzzy MPPT and energy management for bifacial PV and battery-powered electric vehicle charging system. [PDF]

Sci Rep
Tiwari VK, Kumar A, Yadav S, Nishad DK, Khalid S.   +4 more
europepmc   +1 more source

From Professionalism to Professional Identity: The Emerging Core of Modern Medical Education. [PDF]

Pak J Med Sci
Zaidi SH, Hadi BA.
europepmc   +1 more source

Pauses as a Quantitative Measure of Linguistic Planning Challenges in Parkinson's Disease. [PDF]

Brain Sci
D'Ascanio S, Piras F, Spada C, Pellicano C, Piras F.   +4 more
europepmc   +1 more source

Autism ableism seen through research abstract contents: A mixed-methods analysis of language in NIH-funded genetic and genomic autism research. [PDF]

Autism
Sugden N, Barna LS, Foor K, Kee J, Gunter C.   +4 more
europepmc   +1 more source

FDA approval of prademagene zamikeracel (Zevaskyn): advancing gene therapy for recessive dystrophic epidermolysis bullosa (RDEB) patients. [PDF]

Ann Med Surg (Lond)
Shahid SR, Shahid K, Khalid M, Waafira A.   +3 more
europepmc   +1 more source