Results 71 to 80 of about 17,397 (285)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

TERMINOLOGICAL TURMOIL IN THEORETICAL IDENTIFICATION OF DISCOURSE MARKERS

open access: yesFluminensia: Journal for Philological Research, 2010
Although discourse markers study has become a focus of intensive linguistic research within past three decades, there is still no unified empirically grounded theory on these language units.
Gloria Vickov
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modal connectors conveying doubt in the discourse of humanities and social sciences

open access: yes, 2023
The expression of modality in academic language has been studied from various perspectives. Much scholarly attention has been paid to the expression of epistemic modality, which conveys the author’s position in an academic text. In the context of this type of studies, works that analyse hedging, i .e ., markers of academic discourse that convey the ...
Kuliešienė, Agnė, Zubaitienė, Vilma
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

ANNOTATION MODEL FOR LOANWORDS IN INDONESIAN CORPUS: A LOCAL GRAMMAR FRAMEWORK [PDF]

open access: yes, 2013
There is a considerable number for loanwords in Indonesian language as it has been, or even continuously, in contact with other languages. The contact takes place via different media; one of them is via machine readable medium.
Prihantoro, Prihantoro
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

An examination of IELTS candidates’ performances at different band scores of the speaking test: A quantitative and qualitative analysis

open access: yesCogent Education, 2020
The purpose of this mixed-methods study was to explore Iranian IELTS candidates’ strengths and weaknesses in IELTS Speaking Test in terms of IELTS’s four speaking assessment criteria, namely Fluency and Coherence (FlC), Lexical Resource (LR), Grammar ...
Laleh Dashti, Seyyed Ayatollah Razmjoo
doaj   +1 more source

PEKALONGAN DIALECT IN RAPROX BAND LYRICS [PDF]

open access: yes, 2013
Pekalongan is one of the region that uses Javanese as first language in communication. The language use is different in dialect, it shows the characterist ic of particular region. Pekalongan dialect can be seen in Raprox band lyrics.
Santoso, Didik
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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