Results 121 to 130 of about 167,584 (302)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Transdisciplinary Study of Hedging Strategy in Evaluative Academic Discourse
Вестник Волгоградского государственного университета: Серия 2. ЯзыкознаниеThe article presents the research into hedges and hedging strategy realization in evaluative academic genres viewed from a transdisciplinary perspective.
Elena Yu. Viktorova
doaj +1 more source
, 2013 Im Kikuyu, einer in Kenia gesprochenen Bantusprache, wird Fokus systematisch durch Wortstellung markiert. In dieser Arbeit werden die verschiedenen Varianten der Markierung von Fokus in Frage-Antwortsequenzen dargestellt. Nach einem Überblick über in der
Schwarz, Florian
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Focus or narrative constructions? : Morphosyntactically marked focus constructions in some Gur and Kwa languages [PDF]
, 2009 0. Introduction 1. Observations concerning the structure of morphosyntactically marked focus constructions 1.1 First observation: SF vs. NSF asymmetry 1.2 Second observation: NSF-NAR parallelism 1.3 Affirmative ex-situ focus constructions (SF, NSF), and ...
Fiedler, Ines, Schwarz, Anne
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Microgenesis, Method and Object: A Study of Collaborative Activity in a Spanish as a Foreign Language Classroom [PDF]
, 2007 Ganem Gutierrez, A
core +1 more source
Classifying conditionals: The case of metalinguistic 'if you like' [PDF]
, 2015 It is agreed that metalinguistic ‘if you like’ puts some aspect of communication into metalinguistic focus, serving the pragmatic function of commenting upon the appropriateness of the words uttered, but there is little consensus as to whether ...
Elder, Chi-He
core