Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Multifunctionality in the translation of the discourse marker pues [PDF]
, 2019 El presente estudio versa sobre la multifuncionalidad de los marcadores discursivos y propone un estudio de caso sobre las funciones discursivas asumidas por el operador pues. El objetivo del trabajo es descriptivo y traductológico.
Fuentes Rodríguez, Catalina +1 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Direct speech, subjectivity and speaker positioning in London English and Paris French [PDF]
, 2018 This paper examines functional similarities and differences in the use of pragmatic features – in particular quotatives and general extenders – on the right and left periphery of direct quotations.
Andersen +11 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Teaching and Professional Fellowship Report 2004/5 : Structured vivas as accommodated assessment for dyslexic students [PDF]
, 2005 The central goal of this report was to produce guidelines in audio and written form for dyslexic students wishing to undertake accommodated assessment, specifically the viva voce within creative degrees at UAL. The avenues of exploration were to work
Symonds, Heather
core
Welche Sprache ist sie anyway?: Borrowed anyway/anyhow in Texas German [PDF]
, 2018 A common phenomenon when languages are in contact is for one language to borrow words or phrases from another and incorporate them into the native vocabulary.
Jesswein, Victoria
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Ingroup/outgroup dynamics and agency markers in Italian parliamentary language. A gender-based socio-psychological analysis of the speeches of men and women deputies (2001 and 2006). [PDF]
, 2017 The most recent literature on gender differences in language use has shown that the Italian political communication enacted by men and women parliamentarians only partly reflects and reproduces the asymmetries and stereotypes widespread in society ...
ARENI, Alessandra +2 more
core +1 more source