Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The use of discourse markers in argumentative compositions by Jordanian EFL learners. [PDF]
Huneety A +4 more
europepmc +1 more source
Interruptions Produced by the Mollucan Students in the Fellowship Meeting [PDF]
This thesis is about a study of the interruptions produced by the Moluccan students in a fellowship meeting, consisting of fifteen students as the respondents, who are divided into two: the chairperson and the members.
Silalebit, M. A. (Marcelin) +1 more
core
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Special Distribution of Discourse Markers Determined by Genre-Specific Scientific Discourse
The article is concerned with the role of discourse markers in denoting the genre of some text or utterance. The analysis is based on proper scientific discourse, including such genres as a monograph, article, lecture and discussion.
Olesya A. Zagorodnova
doaj +1 more source
Retracted: Cognitive Analysis of Pragmatic Functions of Discourse Markers in Spoken English in the Context of Computational Intelligence. [PDF]
Environmental And Public Health JO.
europepmc +1 more source
Discourse Marker Sequencing and Grammaticalization
In lieu of an abstract, here is a brief excerpt:This paper deals with the grammatical properties of discourse markers (DMs), specifically their ordering preferences relative to one another. While the data presented here are synchronic, we approach the topic of DM sequencing from the perspective of grammaticalization.
Koops, Christian, Lohmann, Arne
openaire +3 more sources
Situating Grammar Instruction in the World Language Classroom: Four Content-Enriched Strategies [PDF]
The role of grammar instruction in promoting communicative competence continues to be a controversial issue for the world language classroom teacher. Second language acquisition research suggests that critical to sustained progress in language use is a ...
Hernández, Todd A.
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source

