Results 111 to 120 of about 1,858,196 (253)
, 2019 We report on three experiments that aim at measuring the role of prosody in the acceptability and interpretation of discourse relations between utterances connected by two French discourse markers, viz. et “and” and alors “then/well.” These two discourse
Simon, Anne-Catherine +3 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Discourse markers in Spanish [PDF]
The chapter offers a systematic overview of the four most relevant approaches in the synchronic research on discourse marking in Spanish along with their respective theoretical frameworks.
Eugenia Sainz, Laura Nadal
core
Научный диалогThis article addresses the issue of discourse markers as illuminated by the works of Russian scholars. The relevance of the study is justified by the necessity of theoretical understanding of existing scientific approaches to the examination of these ...
A. V. Kuleshova, T. V. Slastnikova
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Importance marking: Giving reference to the highlighted discourse in academic lectures [PDF]
Ibérica, 2017 This study was an attempt to explore how important points are highlighted in Persian academic lectures. More specifically, this paper was aimed to reach a taxonomy of importance markers based on (a) the discourse functions of importance markers, and (b ...
Javad Zare , Keivanloo-Shahrestanaki
doaj
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Relevance and linguistic meaning: the semantics and pragmatics of discourse markers
, 2002 The importance of discourse markers (words like "so," "however," and "well") lies in the theoretical questions they raise about the nature of discourse and the relationship between linguistic meaning and context. Diane Blakemore asserts that the exercise
Blakemore, D
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source