Results 131 to 140 of about 20,639 (306)

Pour ou contre une relation de Reformulation ? Un début de réponse

open access: yesDiscours
This article offers a discussion and some elements on the characterization of the notion of restatement by focusing on the following question: in formal discourse approaches, should restatement be added as a discourse relation in its own or as a subtype ...
Hélène Vassiliadou, Joan Busquets
doaj   +1 more source

A corpus-driven approach to discourse organisation: from cues to complex markers

open access: yes, 2017
International audienceThis paper reports on an experiment implementing a data-intensive approach to discourse organisation. Its focus is on enumerative structures envisaged as a type of textual pattern in a sequentiality-oriented approach to discourse ...
Fabre, Cécile   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Discourse and pragmatic markers from Latin to the Romance languages: new insights

open access: yes, 2014
Functional markers operating within the pragmatic domain are extremely common in interaction. These items are often used by speakers strategically in communicative exchanges, and can perform a number of functions which index discourse organization, the ...
GHEZZI, Chiara (ORCID:0000-0002-7016-1657)   +1 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

On temporality in discourse annotation: Theoretical and practical considerations

open access: yes, 2017
Temporal information is one of the prominent features that determine the coherence in a discourse. That is why we need an adequate way to deal with this type of information during discourse annotation.
Hoek, Jet   +5 more
core  

Discourse Markers: What are they and where do they come from?

open access: yes
In this editors' introduction to the volume, we first seek to briefly place the study of discourse markers within the study of (Romance) linguistics more broadly, outlining some of the ways in which Romance linguists have been at the forefront of ...
Jacqueline Visconti
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

David cameron's discourse markers in the andrew marr show

open access: yes, 2015
viii, 52 hlm,; ilus,; 30 ...
Abdul Halim   +3 more
core  

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