Results 151 to 160 of about 20,639 (306)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Variation in discourse marker use. Position matters!
, 2014 Discourse markers have been described as typically occurring in utterance-initial position, also described as left-peripheral position. But more recently, discourse markers occurring at utterance-final, or right-peripheral position have attracted quite ...
Discourse-Pragmatic Variation & Change 2 +1 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
MEANING NEGOTIATION IN ACADEMIC DISCOURSE: A TYPOLOGY OF CITATIONS AS SEMANTIC MARKERS
, 2018 In academic discourse, citations constitute a multifunctional pragmatic act: they acknowledge the property rights of writers, create intellectual or conceptual linkages, and enhance the persuasiveness of a text.
Collet, Tanja
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Automatic discourse markers extractor
This work is framed in the Spanish national project CLARA-FINT. The aim of this task within the project was to create an automatic discourse markers extractor for Spanish.
García Toro, Ana +2 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
On the Persistence of Discourse Predictions: The Facilitative Effect of Discourse Markers Diminishes in the Presence of Intervening Material. [PDF]
Open Mind (Camb)Scholman MCJ, Rohde H, Demberg V.
europepmc +1 more source
WHERE FOCUS FORMULAS AND DISCOURSE MARKERS MEET
, 2015 Our paper, theoretically anchored in functional and systemic grammar, focuses on a relatively marginal type of focus formulas (FFs), referred to by Schmid (2001) as ‘N-bethat- constructions’ or constructions with shell-Nouns (cf. The trouble/problem/fact…
Tárnyiková, Jarmila, Válková, Silvie
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