Results 121 to 130 of about 732 (204)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Relatos de práticas docentes: o discurso do sujeito coletivo desvelando suas contribuições = Teacher practice reports: the collective subject discourse unveiling their contributions = Informes de prácticas de enseñanza: el discurso del sujeto colectivo desvelando sus contribuciones

Educação, 2017
As sessões de apresentação de relatos de prática já fazem parte da programação dos Seminários Web Currículo, promovidos pelo Programa de Pós-Graduação em Educação: Currículo da Pontifícia Universidade Católica de São Paulo (PUC-SP). Visando a compreender as contribuições das apresentações de tais práticas, sob a perspectiva dos participantes nas ...
Gonçalves, Lina Maria, Perrier, Gerlane Romão Fonseca, Almeida, Maria Elizabeth Bianconcini de   +2 more
openaire   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Grupo focal e discurso do sujeito coletivo: produção de conhecimento em saúde de adolescentes Grupos de enfoque y discurso del sujeto colectivo: produción de conocimientos sobre la salud de los adolescentes Focal group and discourse on the collective subject: knowlegde production in health of adolescents

Escola Anna Nery, 2009
Objetivou-se discutir o emprego do Grupo Focal (GF) para coleta e do Discurso do Sujeito Coletivo (DSC) para análise de dados em investigações no Campo da Enfermagem. Essas técnicas foram descritas sob o ponto de vista teórico e prático. Exemplificou-se o emprego pelo detalhamento das etapas metodológicas, de uma pesquisa aprovada em comitê de ética ...
Vera Lúcia de Oliveira Gomes, Kátia da Silva Telles, Evelyn de Castro Roballo   +2 more
openaire   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Discourse of the collective subject in the qualitative evaluation of pos-graduation "lato sensu" Courses: Training and Development of Health Manpower - CADRHU, São Paulo - 2002

, 2003
This article makes an the evaluation of the satisfaction, among students of the course: "Training and development of manpower in Health " - CADRHU 2002" , that was offered by the Health State Secretary and Public Health School/USP. In order to do that, the authors used the technical devices of the Discourse of the Collective Subject (Lefèvre e Lefèvre,
Lefevre, Ana Maria Cavalcanti, Crestana, Maria Fazanelli, Cornetta, Vitória Kedy   +2 more
openaire   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source