Results 121 to 130 of about 1,243,760 (302)
Nordicum-Mediterraneum, 2012 This article has two main currents. First, it argues that an affinity or similarity can be identified between the philosophy of Gianni Vattimo (the so-called “Weak Thinking”) and the “Discourse Theory” of Ernesto Laclau and Chantal Mouffe.
Andreas Hjort Bundgaard
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The Many Functions of Discourse Particles: A Computational Model of Pragmatic Interpretation [PDF]
, 1997 We present a connectionist model for the interpretation of discourse\ud particles in real dialogues that is based on neuronal\ud principles of categorization (categorical perception, prototype\ud formation, contextual interpretation).
Fischer, Kerstin, Scheler, Gabriele
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The Role of Qualitative Interviews in Discourse Theory
Critical Approaches to Discourse Analysis across Disciplines, 2012 In discourse theoretical studies the qualitative interview is scarcely treated as a method, but as empirical data. Some important methodological challenges for discourse theory are thereby being obscured.
Jørn Cruickshank
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Forum: Qualitative Social Research, 2007 Following the thoughts of LACLAU and MOUFFEs hegemony theories, NONHOFF develops hegemony and hegemonic strategies as discoursive phenomena. He identifies core strategies which put political projects in hegemonic positions.
Silke Schneider
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Capitalistic Competition as a Communicative Community - Why Politics Is Less “Deliberative” than Markets [PDF]
Discourse theorists such as Habermas tend to disregard the communicative character and discoursive power of market processes and at the same time overrate the ability of political deliberation to discover and implement social problem solutions ...
Wohlgemuth, Michael
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