Results 131 to 140 of about 54,162 (265)

Indeterminate Multiplicity and the Multiplicity of Indeterminacies: Social Ontology at the Intersection of (Post) Structuralist Intuitions

open access: yesСоциология власти
The article positions the concept of uncertainty as a central element of social ontology. By drawing on the resources of Ernesto Laclau and Chantal Mouffe’s discourse theory, the author argues for the fundamental impossibility of meanings fixation and ...
S. S. Balishyan
doaj  

Communication and Discourse Theory: Collected Works of the Brussels Discourse Theory Group

open access: yes, 2019
The introduction to the edited volume Communication and Discourse Theory aims to reflect on the interaction between discourse theory and the study of media and communication, as well as the Brussels Discourse Theory Group’s contribution to it. The chapter starts with a summary of the main tenets of Laclau and Mouffe’s discourse theory, and touches upon
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Media and Propaganda| “Today’s Children, Tomorrow’s Mujahideen”: A Discourse-Theoretical Analysis of the Militarist Discourse in a Turkish Cypriot Children's Magazine

open access: yesInternational Journal of Communication
This research offers a discourse-theoretical analysis of the construction of the militarist discourse in Turkish Cypriot children’s magazines, with a specific focus on the magazine Tuncer.
Mazlum Kemal Dagdelen
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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