Results 111 to 120 of about 79,871 (304)

INTERNET-DISCOURSE IN DISCOURSE PARADIGM

open access: yesГуманитарные и юридические исследования, 2021
The article represents the analysis of computer-based discourse within the frame of global discourse system, its differences from other types of discourse and peculiarities preconditioned by electronic communication channel.
E. K. Rusanov
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

A discourse-based approach to verb placement in early West-Germanic [PDF]

open access: yes, 2006
The paper presents a novel approach to explaining word order variation in the early Germanic languages. Initial observations about verb placement as a device marking types of rhetorical relations made on data from Old High German (cf.
Petrova, Svetlana
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Annotating a corpus of Early Modern English writing for categories of discourse presentation [PDF]

open access: yes, 2012
This article discusses the process of annotating a small corpus of Early Modern English writing that we have constructed in order to investigate the diachronic development of speech, writing and thought presentation.
Walker, Brian, McIntyre, Dan
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Web design discourse and access : a case study of student entry into a web design Discourse in the Multimedia Technology programme at CPUT [PDF]

open access: yes, 2006
Includes bibliographical references (leaves 109-117).This thesis represents an instance of my engagement as a reflective practitioner to explore how access opportunities into a web design Discourse can be enhanced.
Coleman, Lynn
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Evoking the Possibility of Presence:Textual and Ideological Effects of Linguistic Negation in Written Discourse [PDF]

open access: yes
This thesis explores the textual and ideological effects of linguistic negation in written texts. It argues that when language users process negation, understanding its use in context is as much about the possibility of presence as it is about the ...
Nahajec, Lisa Margaret
core  

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