Results 91 to 100 of about 52,498 (263)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Contextually Determined Coherence as a Backbone to Discourse Typology
Дискурс профессиональной коммуникацииThe diversity of discourse types encountered in linguistics presents a significant challenge to establishing a universally applicable classification system.
E. S. Solntseva
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Udmurt particles ja and nu: what’s the difference?
Eesti ja Soome-ugri Keeleteaduse AjakiriIn this paper, we compare semantic-pragmatic profiles of two discourse (modal) particles, ja and nu, in Udmurt and Beserman (Permic < Uralic), using a mixed-method approach.
Iuliia Zubova, Timofey Arkhangelskiy
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Discourse- and lesion-based aphasia quotient estimation using machine learning
NeuroImage: ClinicalDiscourse is a fundamentally important aspect of communication, and discourse production provides a wealth of information about linguistic ability. Aphasia commonly affects, in multiple ways, the ability to produce discourse.
Nicholas Riccardi +5 more
doaj +1 more source
DIPLOMATIC DISCOURSE AS AN INDEPENDENT TYPE OF DISCOURSE
Humanities science current issues, 2022 openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FUNCTIONAL TYPES OF METAPHORS IN RUSSIAN AND ENGLISH SPORTING DISCOURSE
Russian Language Studies, 2015 Many words have both literal and transferred (metaphorical) meanings whereby literal meaning is basic, and transferred meaning has the sense different from the basic one.
A N Gritsenko
doaj