Results 81 to 90 of about 79,871 (304)

BUILDING UNDERSTANDING IN ASYCHRONOUS DISCUSSIONS: EXAMINING TYPES OF ONLINE DISCOURSE

open access: yesOnline Learning, 2019
This article describes a study exploring how students’ learning is reflected in asynchronous online discussion. The study examined how online discourse contributes to the learning process.
Seungyeon Han, Janette R. Hill
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Semantic Knowledge Use in Different Discourse Types [PDF]

open access: yes, 2016
Semantic knowledge is an individual’s internal representations of a given object. In turn, semantic memory relates to the general knowledge and memory systems an individual uses for understanding concepts. Concepts are grouped into categories.
Abashian, Caroline R
core   +2 more sources

Discourse Manifestation of Personality

open access: yesRussian journal of linguistics: Vestnik RUDN, 2016
The paper deals with approaches to discourse studies. The approaches may be regarded as discourse dimensions associated with models presented and substantiated by M.M. Bakhtin, J. Habermas, Yu.M. Lotman and M.A.K. Halliday.
Vladimir I Karasik
doaj   +1 more source

Advertising discourse as one of institutional discourse types

open access: yesVìsnik Marìupolʹsʹkogo deržavnogo unìversitetu. Serìâ: Fìlologìâ, 2019
The paper is devoted to the analysis of advertising discourse as one of the institutional types from the linguopragmatics perspective. In this aspect, the main features of advertising discourse are presented, the features of advertising text are characterized, specific features of advertising communication are outlined and strategies for influencing ...
openaire   +1 more source

Speech act theory, discourse structure and indirect speech [PDF]

open access: yes, 1991
Speech Act Theory is concerned with the ways in which language can be used. It originated with Austin, but was developed by Searle. The theories of Austin and Searle are described and several problem areas are identified.
Smith, Peter Wilfred Hesling
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Discourse, of Course An overview of research in discourse studies [PDF]

open access: yes
Discourse, of Course comes after Jan Renkema's Introduction to Discourse Studies (2004) for undergraduates. The new book is a collection of twenty short papers. It is a capita selecta course and meant for graduate programs.
Renkema, Jan.
core  

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