Results 31 to 40 of about 24,765 (260)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Nature CommunicationsSclerostin, which has three loops, inhibits bone formation and impairs whole-body lipid and glucose metabolism. The marketed therapeutic sclerostin antibody for postmenopausal osteoporosis (POP) mainly targeting loop2 promotes bone formation and improves
Hewen Jiang +28 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Radar efficiency and the calculation of decade-long PMSE backscatter cross-section for the Resolute Bay VHF radar [PDF]
Annales Geophysicae, 2009 The Resolute Bay VHF radar, located in Nunavut, Canada (75.0° N, 95.0° W) and operating at 51.5 MHz, has been used to investigate Polar Mesosphere Summer Echoes (PMSE) since 1997.
N. Swarnalingam +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Análise Multivariada de Dados Ecológicos da Baía de Guanabara- RJ,com Base em Foraminíferos Bentônicos. [PDF]
Anuário do Instituto de Geociências, 2007 Guanabara bay is an estuary environment situated in the seaboard of Rio de Janeiro state, under the coordinates 22º 40’ and 23º 00’S and 43º 00’ and 43º 20’W.
Priscila Tavares dos Santos +5 more
doaj
Discovery and significance of subtle buried hills in Jiyang Depression, Bohai Bay Basin
Shiyou shiyan dizhi, 2020 The exploration of carbonate buried-hills in the Lower Paleozoic in the Jiyang Depression of the Bohai Bay Basin are at a minimum now, and the exploration targets are not clear.
Lichi MA, Yongshi WANG, Anyu JING
doaj +1 more source
Immunotherapy and targeted therapy for lung cancer: Current status and future perspectives
Frontiers in Pharmacology, 2022 Lung cancer has the highest incidence of morbidity and mortality throughout the globe. A large number of patients are diagnosed with lung cancer at the later stages of the disease.
Bilal Zulfiqar +3 more
doaj +1 more source