Results 51 to 60 of about 299,979 (205)
Frontiers in Cellular Neuroscience, 2019 The dysfunction of the hypothalamus–pituitary–adrenal (HPA) axis is often seen in Alzheimer’s disease (AD) patients with cognitive deficits. Selective inhibition of phosphodiesterase (PDE) 4 and 5 has already proven to be effective in reducing beta ...
Lina Ruan +10 more
doaj +1 more source
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor
Journal of Medicinal ChemistryThe matrix metalloprotease ADAMTS7 has been identified by multiple genome-wide association studies as being involved in the development of coronary artery disease. Subsequent research revealed the proteolytic function of the enzyme to be relevant for atherogenesis and restenosis after vessel injury.
Daniel Meibom +20 more
openaire +2 more sources
Microorganisms, 2013 As the need for new and more effective antibiotics increases, untapped sources of biodiversity are being explored in an effort to provide lead structures for drug discovery.
Andrew J. Flewelling +5 more
doaj +1 more source
The lure of texts and the discipline of praxis: cross-cultural history in a post-empirical world [PDF]
, 2015 The main aim of this paper is to tell stories about interactions between European voyagers and Aboriginal people in New Holland (mainland Australia) and Van Diemen's Land (Tasmania) at the end of the eighteenth ...
Douglas, Bronwen
core
BioInvasions Records, 2013 The Asiatic isopod Paranthura japonica Richardson, 1909 was collected in 2007 in Arcachon Bay (SW France), where the species occurs in a variety of habitats, both in the intertidal and at shallow depths. This species, native to the Sea of Japan, may have been accidentally introduced in Arcachon Bay with oyster transfers or as fouling on ship hulls.
Lavesque, Nicolas +7 more
openaire +2 more sources
Neutrino Oscillation Studies with Reactors
, 2015 Nuclear reactors are one of the most intense, pure, controllable, cost-effective, and well-understood sources of neutrinos. Reactors have played a major role in the study of neutrino oscillations, a phenomenon that indicates that neutrinos have mass and ...
Vogel, Petr, Wen, Liangjian, Zhang, Chao
core +1 more source
Acta Biochimica et Biophysica SinicaProtein disulfide isomerase (PDI) was recently shown to be an upstream mediator of erastin-induced, glutathione depletion-associated ferroptosis through its catalysis of nitric oxide synthase (NOS) dimerization
Hou Ming-Jie, Huang Xuanqi, Zhu Bao Ting
doaj +1 more source
Search for Bioindicators of Pollution in the Guanabara Bay: Integrations of Ecologic Patterns [PDF]
Anuário do Instituto de Geociências, 2003 Guanabara Bay, since its discovery, has largely changed with the human occupation causing large amounts of deposited sediment and waste, as well as domestic and industry sewage. Surface sediment was analysed for foraminifera and ostracoda distribution,
Claudia G. Vilela +5 more
doaj
Salt Marsh Values in a Changing World: Examining Sea Level Rise on Tidal Marshes with a Surface Elevation Table [PDF]
, 2014 Rising seas are threatening coastal communities and putting added pressures on the natural environment. Sea level rise rates are increasing on a global scale (from 1.7 to 3.2 mm/yr).
Tierney, Sarah Martina
core +1 more source
Neutrino factory in stages: Low energy, high energy, off-axis
, 2010 We discuss neutrino oscillation physics with a neutrino factory in stages, including the possibility of upgrading the muon energy within the same program. We point out that a detector designed for the low energy neutrino factory may be used off-axis in a
Jian Tang, P. Huber, Walter Winter
core +1 more source