Results 141 to 150 of about 19,470,595 (297)

Corrigendum: Bio-TDS: bioscience query tool discovery system. [PDF]

Nucleic Acids Res, 2018
Gnimpieba EZ, VanDiermen MS, Gustafson SM, Conn B, Lushbough CM.   +4 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Variable and dynamic associations between hot weather, thermal comfort, and individuals’ emotional states during summertime

BMC Psychology
The effects of heat exposure on negative affect are thought to be central to the observed relationships between hot summer days and deleterious outcomes, such as violent crime or mental health crises.
Kimberly L. Meidenbauer, Kathryn E. Schertz, Peiyuan Li, Ashish Sharma, Tiara R. Freeman, Elizabeth A. Janey, Andrew J. Stier, Anya L. Samtani, Kathryn Gehrke, Marc G. Berman   +9 more
doaj   +1 more source

LION LBD: a literature-based discovery system for cancer biology. [PDF]

Bioinformatics, 2019
Pyysalo S, Baker S, Ali I, Haselwimmer S, Shah T, Young A, Guo Y, Högberg J, Stenius U, Narita M, Korhonen A.   +10 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Towards an Integrated Discovery System.

, 1987
Previous research on machine discovery has focused on limited parts of the empirical discovery task. In this paper we describe IDS, an integrated system that addresses both qualitative and quantitative discovery. The program represents its knowledge in terms of qualitative schemas, which it discovers by interacting with a simulated physical environment.
Nordhausen, Bernd, Langley, Pat
openaire   +2 more sources

Understanding pathways from implementation to sustainment: a longitudinal, mixed methods analysis of promising practices implemented in the Veterans Health Administration

Implementation Science
Background The Veterans Health Administration (VHA) is the United States largest learning health system. The Diffusion of Excellence (DoE) program is a large-scale model of diffusion that identifies and diffuses evidence-informed practices across VHA ...
Andrea L. Nevedal, Marilla A. Opra Widerquist, Caitlin M. Reardon, Maria Arasim, George L. Jackson, Brandolyn White, Madison Burns, Gemmae M. Fix, Kathryn DeLaughter, Sarah L. Cutrona, Allen L. Gifford, Guneet K. Jasuja, Timothy P. Hogan, Heather A. King, Blake Henderson, Laura J. Damschroder   +15 more
doaj   +1 more source

Bio-TDS: bioscience query tool discovery system. [PDF]

Nucleic Acids Res, 2017
Gnimpieba EZ, VanDiermen MS, Gustafson SM, Conn B, Lushbough CM.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source