Results 41 to 50 of about 19,121 (268)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Rapid Prototyping of Field Programmable Gate Array-Based Discrete Cosine Transform Approximations
EURASIP Journal on Advances in Signal Processing, 2003 A method for the rapid design of field programmable gate array (FPGA)-based discrete cosine transform (DCT) approximations is presented that can be used to control the coding gain, mean square error (MSE), quantization noise, hardware cost, and power ...
Trevor W. Fox, Laurence E. Turner
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Construction of algebraic-analytic discrete approximations for linear and nonlinear hyperbolic equations in R^{2}. Part I [PDF]
Opuscula Mathematica, 2007 An algebraic-analytic method for constructing discrete approximations of linear hyperbolic equations based on a generalized d'Alembert formula of the Lytvyn and Riemann expressions for Cauchy data is proposed.
Mirosław Luśtyk, Mykola Prytula
doaj
Entropy, 2019 Although Shannon mutual information has been widely used, its effective calculation is often difficult for many practical problems, including those in neural population coding.
Wentao Huang, Kechen Zhang
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Approximations of the ruin probability in a discrete time risk model
Modern Stochastics: Theory and Applications, 2020 Based on a discrete version of the Pollaczeck–Khinchine formula, a general method to calculate the ultimate ruin probability in the Gerber–Dickson risk model is provided when claims follow a negative binomial mixture distribution.
David J. Santana, Luis Rincón
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Separations, 2021 The article revisits the discrete recurrence method to model the instruments of liquid–liquid partition chromatography as counter-current chromatography (CCC) and centrifugal partition chromatography (CPC).
Frédéric R. Dijoux, Tsvetelina Mandova
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