Results 51 to 60 of about 152,792 (262)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Preferences for Outcomes Among Adults with Type 1 Diabetes and Caregivers of Children with Type 1 Diabetes

Patient Preference and Adherence, 2020
Marjana Marinac,1 Jessie Sutphin,2 Campbell Hutton,1 Kathleen Klein,2 Sean Sullivan,3 Carol Mansfield2 1JDRF, Washington, DC, USA; 2RTI Health Solutions, Research Triangle Park, NC, USA; 3The Leona M. and Harry B.
Marinac M, Sutphin J, Hutton C, Klein K, Sullivan S, Mansfield C   +5 more
doaj  

Combining Actual and Contingent Behavior Data to Model Farmer Adoption of Water Quality Protection Practices

Journal of Agricultural and Resource Economics, 1997
Using farmer responses to contingent valuation method (CVM) survey data in combination with actual market data from four watershed regions in the United States, this study estimates the minimum incentives payments a farmer would accept in order to adopt ...
Joseph C. Cooper
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Optimasi Tarif Kereta Bandara Soekarno-Hatta dengan Model Permintaan Berbasis Discrete Choice Experiment

Jurnal Teknik Sipil, 2021
Penelitian ini bertujuan menentukan tarif optimal Kereta Bandara Soekarno Hatta dengan fungsi permintaan yang diturunkan dengan pendekatan discrete-choice experiment.
Fransiscus Rian Pratikto, Mathew Zephaniah Samtani   +1 more
doaj   +1 more source

Beyond discrete-choice options

Trends in Cognitive Sciences
While decision theories have evolved over the past five decades, their focus has largely been on choices among a limited number of discrete options, even though many real-world situations have a continuous-option space. Recently, theories have attempted to address decisions with continuous-option spaces, and several computational models have been ...
Rasanan, Amir Hosein Hadian, Evans, Nathan J., Fontanesi, Laura, Manning, Catherine, Huang-Pollock, Cynthia, Matzke, Dora, Heathcote, Andrew, Rieskamp, Jörg, Speekenbrink, Maarten, Frank, Michael J., Palminteri, Stefano, Lucas, Christopher G., Busemeyer, Jerome R., Ratcliff, Roger, Rad, Jamal Amani   +14 more
openaire   +4 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Inflammatory bowel disease patients prioritize mucosal healing, symptom control, and pain when choosing therapies: results of a prospective cross-sectional willingness-to-pay study

Patient Preference and Adherence, 2018
James C Gregor,1 Martin Williamson,2 Dorota Dajnowiec,2 Bernie Sattin,2 Erik Sabot,3 Baljinder Salh4 1Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; 2Janssen Inc., Toronto, ON, Canada; 3OptumInsight, Boston,
Gregor JC, Williamson M, Dajnowiec D, Sattin B, Sabot E, Salh B   +5 more
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source