Results 51 to 60 of about 153,229 (263)

On substitutability and complementarity in discrete choice models

Operations Research Letters, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Guiyun Feng, Xiaobo Li 0002, Zizhuo Wang 0001   +2 more
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inflammatory bowel disease patients prioritize mucosal healing, symptom control, and pain when choosing therapies: results of a prospective cross-sectional willingness-to-pay study

Patient Preference and Adherence, 2018
James C Gregor,1 Martin Williamson,2 Dorota Dajnowiec,2 Bernie Sattin,2 Erik Sabot,3 Baljinder Salh4 1Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; 2Janssen Inc., Toronto, ON, Canada; 3OptumInsight, Boston,
Gregor JC, Williamson M, Dajnowiec D, Sattin B, Sabot E, Salh B   +5 more
doaj  

Stimulating agritourism loyalty in the Mid-Atlantic states of the USA

Tourism
Agritourism as a niche tourism market has become an alternative income-generating sector for conventional farmers that focus on both production and marketing.
Rahmiye Figen Ceylan, Ramu Govindasamy, Burhan Ozkan, Sonal Pandey   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Determinants of households’ investment in energy efficiency and renewables: evidence from the OECD survey on household environmental behaviour and attitudes

Environmental Research Letters, 2015
This paper provides novel evidence on the main factors behind consumer choices regarding investments in energy efficiency and renewable energy technologies using the OECD Survey on Household Environmental Behaviour and Attitudes.
Nadia Ameli, Nicola Brandt
doaj   +1 more source

Beyond discrete-choice options

Trends in Cognitive Sciences
While decision theories have evolved over the past five decades, their focus has largely been on choices among a limited number of discrete options, even though many real-world situations have a continuous-option space. Recently, theories have attempted to address decisions with continuous-option spaces, and several computational models have been ...
Rasanan, Amir Hosein Hadian, Evans, Nathan J., Fontanesi, Laura, Manning, Catherine, Huang-Pollock, Cynthia, Matzke, Dora, Heathcote, Andrew, Rieskamp, Jörg, Speekenbrink, Maarten, Frank, Michael J., Palminteri, Stefano, Lucas, Christopher G., Busemeyer, Jerome R., Ratcliff, Roger, Rad, Jamal Amani   +14 more
openaire   +4 more sources

Combinatorial Discrete Choice [PDF]

SSRN Electronic Journal, 2017
Discrete choice problems with complementarities are prevalent in economics but the large dimensionality of potential solutions substantially limits the scope of their application. We define and characterize a general class that we term combinatorial discrete choice problems and show that it covers many existing problems in economics and engineering. We
Costas Arkolakis, Fabian Eckert
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source