Results 51 to 60 of about 2,437,029 (311)

On substitutability and complementarity in discrete choice models

open access: yesOperations Research Letters, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Guiyun Feng   +2 more
openaire   +5 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Using discrete choice modellinng to investigate breast screening participation

open access: yes, 2008
The aim of this chapter is to show how discrete choice experiments (DCEs) can be applied to examine the preferences of women reinvited for breast screening and to use the results in developing breast screening participation enhancement ...
Gerard, Karen   +8 more
core   +1 more source

Inflammatory bowel disease patients prioritize mucosal healing, symptom control, and pain when choosing therapies: results of a prospective cross-sectional willingness-to-pay study

open access: yesPatient Preference and Adherence, 2018
James C Gregor,1 Martin Williamson,2 Dorota Dajnowiec,2 Bernie Sattin,2 Erik Sabot,3 Baljinder Salh4 1Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada; 2Janssen Inc., Toronto, ON, Canada; 3OptumInsight, Boston,
Gregor JC   +5 more
doaj  

Stimulating agritourism loyalty in the Mid-Atlantic states of the USA

open access: yesTourism
Agritourism as a niche tourism market has become an alternative income-generating sector for conventional farmers that focus on both production and marketing.
Rahmiye Figen Ceylan   +3 more
doaj   +1 more source

Consumer Behavior in the Choice of Mode of Transport: A Case Study in the Toledo-Madrid Corridor

open access: yesFrontiers in Psychology, 2017
Within the context of the consumption of goods or services the decisions made by individuals involve the choice between a set of discrete alternatives, such as the choice of mode of transport.
Ana I. Muro-Rodríguez   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Combining Actual and Contingent Behavior Data to Model Farmer Adoption of Water Quality Protection Practices

open access: yesJournal of Agricultural and Resource Economics, 1997
Using farmer responses to contingent valuation method (CVM) survey data in combination with actual market data from four watershed regions in the United States, this study estimates the minimum incentives payments a farmer would accept in order to adopt ...
Joseph C. Cooper
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

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