Results 41 to 50 of about 4,657,563 (312)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Discrete choice experiment attributes and levels.

, 2020
Discrete choice experiment attributes and levels.
Gavin George (2950677), Tsitsi B. Masvawure (8367864), Innocent Chingombe (8367873), Martin Msukwa (8367876), Godfrey Musuka (375904), Michael Strauss (550332), Joanne E. Mantell (3196512), Jennifer M. Zech (8367870), Munyaradzi Mapingure (8367861), Matthew R. Lamb (8367867), Clorata Gwanzura (8367882), Rodrigo Boccanera (8367879), Tsitsi Apollo (3559127), Miriam Rabkin (811055)   +13 more
core   +1 more source

Preferences of Hungarian consumers for quality, access and price attributes of health care services — result of a discrete choice experiment [PDF]

, 2012
In 2010, a household survey was carried out in Hungary among 1037 respondents to study consumer preferences and willingness to pay for health care services.
Groot, W., Pavlova, Milena, Groot, Wim, Baji, Petra, Baji, P., Gulácsi, László, Pavlova, M., Gulácsi, L., László Gulácsi, Milena Pavlova, Wim Groot, Petra Baji   +11 more
core   +1 more source

Medical Personnel Behavior Preferences for Providing mHealth Service in China: A Discrete Choice Experiment

Risk Management and Healthcare Policy, 2023
Shuai Jiang,1,2 Man Xiong,3 Xinyi Rao,3 Jieting Liang,3 Xinghan Zhu,3 Hang Fu,1,2 Jiangyun Chen,3 Chengzeng Wang1,2 1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Institute for Hospital Management ...
Jiang S, Xiong M, Rao X, Liang J, Zhu X, Fu H, Chen J, Wang C   +7 more
doaj  

Environmental Valuation with Discrete Choice Experiments

, 2021
AT_PUBLICATION
Mariel, Petr, Hoyos, David, Meyerhoff, Jürgen, Czajkowski, Mikolaj, Dekker, Thijs, Glenk, Klaus, Bredahl Jacobsen, Jette, Liebe, Ulf, Olsen, Søren Bøye, Sagebiel, Julian, Thiene, Mara   +10 more
openaire   +2 more sources

Reconceptualising the External Validity of Discrete Choice Experiments

PharmacoEconomics, 2014
External validity is a crucial but under-researched topic when considering using discrete choice experiment (DCE) results to inform decision making in clinical, commercial or policy contexts. We present the theory and tests traditionally used to explore external validity that focus on a comparison of final outcomes and review how this traditional ...
Emily, Lancsar, Joffre, Swait
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source