Results 81 to 90 of about 8,708,943 (308)
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Discrete Choice Survey Experiments: A Comparison Using Flexible Models [PDF]
This study investigates the convergent validity of discrete choice contingent valuation (CV) and contingent rating/ranking (CR) methods using flexible econometric methods. Our results suggest that CV and CR can produce consistent data (achieve convergent
Siikamaki, Juha, Layton, David F.
core
Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park +5 more
wiley +1 more source
The Use of Binary Choice Forests to Model and Estimate Discrete Choice Models
SSRN Electronic Journal, 2019 Problem definition. In retailing, discrete choice models (DCMs) are commonly used to capture the choice behavior of customers when offered an assortment of products. When estimating DCMs using transaction data, flexible models (such as machine learning models or nonparametric models) are typically not interpretable and hard to estimate, while tractable
Ningyuan Chen +2 more
openaire +2 more sources
The role of the reference alternative in the specification of asymmetric discrete choice models [PDF]
Within the discrete choice modelling literature, there has been growing interest in including reference alternatives within stated choice survey tasks.
John M. Rose, Lorenzo Masiero
core
Computation, efficiency and endogeneity in discrete choice models [PDF]
, 2001 This thesis is a collection of five essays on different research problems related to discrete choice models. The problems, besides being different from each other in nature, also originate from different subdisciplines in economics. However, they have in
Sándor, Zsolt,, Sándor, Zsolt
core +13 more sources
Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay +15 more
wiley +1 more source
ADALS – Beitrag zur DEM-Partikelsimulation in der Landmaschinentechnik
Landtechnik, 2014 The Discrete Element Method (DEM) is the tool of choice for simulation of agricultural material’s processing. For this are needed granular matter models, whose generation and parametrization is costly.
Andreas Prüfer +2 more
doaj +1 more source
Moral rhetoric in discrete choice models: a Natural Language Processing approach. [PDF]
Qual Quant, 2023 Szép T, van Cranenburgh S, Chorus C.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source