Results 61 to 70 of about 103,738 (260)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Implications of Thresholds in Discrete Choice Modelling

open access: yesTransport Reviews, 2006
Abstract Individual choices are affected by complex factors and the challenge consists of how to incorporate these factors in order to improve the realism of the modelling work. The presence of limits, cut‐offs or thresholds in the perception and appraisal of both attributes and alternatives is part of the complexity inherent to choice‐making behaviour.
Cantillo, Victor, Ortuzar, Juan De Dios
openaire   +4 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Approximating Choice Data by Discrete Choice Models

open access: yes, 2022
We obtain a necessary and sufficient condition under which parametric random-coefficient discrete choice models can approximate the choice behavior generated by nonparametric random utility models. The condition turns out to be very simple and tractable.
Chang, Haoge   +2 more
openaire   +2 more sources

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Urban Air Mobility demand forecasting: modeling evidence from the case study of Milan (Italy)

open access: yesEuropean Transport Research Review
This paper presents the results of a demand forecasting study about the introduction of Urban Air Mobility (UAM) services in the metropolitan area of Milan (Italy).
Pierluigi Coppola   +2 more
doaj   +1 more source

Patient preferences for models of care for fibromyalgia: A discrete choice experiment.

open access: yesPLoS ONE
BackgroundFibromyalgia is a common reason for referral to a rheumatologist and is a centralised pain state with symptoms beginning in adolescence/early adulthood and manifests as pain throughout the body, fatigue and cognitive dysfunction.
Patrícia Norwood   +6 more
doaj   +1 more source

Diagnostics in some discrete choice models

open access: yesComputational Statistics & Data Analysis, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Nagel, Herbert, Hatzinger, Reinhold
openaire   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

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