Results 51 to 60 of about 20,624 (255)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

RANDOMLY GENERATED FUZZY DISCRETE DYNAMICAL SYSTEMS [PDF]

Fiabilitate şi Durabilitate
This paper aims to introduce the concept of a fuzzy discrete dynamical system as a fuzzy subgroupoid of X×Z×X, with Z representing the group of integer numbers.
Mădălina Roxana BUNECI
doaj  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Another New Solvable Many-Body Model of Goldfish Type

Symmetry, Integrability and Geometry: Methods and Applications, 2012
A new solvable many-body problem is identified. It is characterized by nonlinear Newtonian equations of motion (''acceleration equal force'') featuring one-body and two-body velocity-dependent forces ''of goldfish type'' which determine the motion ofan ...
Francesco Calogero
doaj   +1 more source

Some Chaotic Properties of Discrete Fuzzy Dynamical Systems

Abstract and Applied Analysis, 2012
Letting (X,d) be a metric space, f:X→X a continuous map, and (ℱ(X),D) the space of nonempty fuzzy compact subsets of X with the Hausdorff metric, one may study the dynamical properties of the Zadeh's extension f̂:ℱ(X)→ℱ(X):u↦f̂u.
Yaoyao Lan, Qingguo Li, Chunlai Mu, Hua Huang   +3 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Discrete-Time Goldfishing

Symmetry, Integrability and Geometry: Methods and Applications, 2011
The original continuous-time ''goldfish'' dynamical system is characterized by two neat formulas, the first of which provides the N Newtonian equations of motion of this dynamical system, while the second provides the solution of the corresponding ...
Francesco Calogero
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Dynamics of a Discretization Physiological Control System [PDF]

Discrete Dynamics in Nature and Society, 2007
We study the dynamics of solutions of discrete physiological control system obtained by Midpoint rule. It is shown that a sequence of Hopf bifurcations occurs at the positive equilibrium as the delay increases and we analyze the stability of the solution of the discrete system and calculate the direction of the Hopf bifurcations.
Xiaohua Ding, Huan Su
openaire   +3 more sources

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source