Results 31 to 40 of about 34,120 (258)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Automated Parcel Locker Configuration Using Discrete Event Simulation

Systems
Automated parcel lockers (APLs) are transforming urban last-mile delivery by reducing failed distributions, decoupling delivery from recipient availability, optimizing carrier routes, reducing carbon foot-print and mitigating traffic congestion.
Eugen Rosca, Floriana Cristina Oprea, Anamaria Ilie, Stefan Burciu, Florin Rusca   +4 more
doaj   +1 more source

Vehicular Network Simulation Environment via Discrete Event System Modeling

IEEE Access, 2019
A vehicular ad-hoc network (VANET) enables vehicles to communicate with each other directly or via roadside infrastructure in order to improve road safety and efficiency.
Le Wang, Renato Iida, Alexander M. Wyglinski   +2 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The impact of ionic anharmonicity on superconductivity in metal-stuffed B-C clathrates

npj Computational Materials
Metal-stuffed B–C compounds with sodalite clathrate structure have captured increasing attention due to their predicted exceptional superconductivity above liquid nitrogen temperature at ambient pressure.
Wenbo Zhao, Ying Sun, Jiaxiang Li, Peng Yuan, Toshiaki Iitaka, Xin Zhong, Hefei Li, Yue-Wen Fang, Hanyu Liu, Ion Errea, Yu Xie   +10 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Data bases and discrete event simulation

Journal of Computer Science and Technology, 2007
This paper is an attempt to define how a specific data structure might be used to store, in a persistent manner, temporal information during a computer simulation.
Abdelhak Boubetra, Hocine Belouadah, Nassreddine Mouhoub   +2 more
doaj  

Modelling Helmet Manufacturing System Using Discrete Event Simulation

Engineering Proceedings
We simulated the manufacturing production line in a micro, small, and medium enterprise (MSME) to assess the efficiency of a helmet product organization, using ARENA simulation modelling software version 15.10.00000.
Khoong Tai Wai, Wan Laailatul Hanim Mat Desa, Lim Li Li, Houng Chien Tan, Chan Ling Meng, Kumara Adji Kusuma   +5 more
doaj   +1 more source