Results 51 to 60 of about 157,604 (263)

Mapping continuous potentials to discrete forms [PDF]

The Journal of Chemical Physics, 2014
The optimal conversion of a continuous inter-particle potential to a discrete equivalent is considered here. Existing and novel algorithms are evaluated to determine the best technique for creating accurate discrete forms using the minimum number of discontinuities.
Thomson, Chris, Lue, L., Bannerman, Marcus N.   +2 more
openaire   +5 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Design of Positive, Negative, and Alternating Sign Generalized Logistic Maps

Discrete Dynamics in Nature and Society, 2015
The discrete logistic map is one of the most famous discrete chaotic maps which has widely spread applications. This paper investigates a set of four generalized logistic maps where the conventional map is a special case.
Wafaa S. Sayed, Ahmed G. Radwan, Hossam A. H. Fahmy   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Wāhi, a discrete global grid gazetteer built using linked open data

International Journal of Digital Earth, 2017
Discrete global grid systems have become an important component of Digital Earth systems. However, previously there has not existed an easy way to map between named places (toponyms) and the cells of a discrete global grid system. The lack of such a tool
Benjamin Adams
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A New Fractional Discrete Memristive Map with Variable Order and Hidden Dynamics

Fractal and Fractional
This paper introduces and explores the dynamics of a novel three-dimensional (3D) fractional map with hidden dynamics. The map is constructed through the integration of a discrete sinusoidal memristive into a discrete Duffing map.
Othman Abdullah Almatroud, Amina-Aicha Khennaoui, Adel Ouannas, Saleh Alshammari, Sahar Albosaily   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Study of Transitivity, Periodic Density and Sensitivity for Chaotic Non-Autonomous Fuzzified Dynamical System [PDF]

Sahand Communications in Mathematical Analysis
The present investigations focus on the mathematical analysis and investigation of non-autonomous discrete dynamical systems. A non-autonomous discrete dynamical system has been framework  using the series technique map method to elaborate the ...
Renu Verma, Ram Yadav
doaj   +1 more source