Results 61 to 70 of about 2,171,485 (241)

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

On The Use of Discrete Cosine Transform Polarity Spectrum in Speech Enhancement

, 2020
This paper investigates the use of short-time Discrete Cosine Transform (DCT) for speech enhancement. We denote the absolute values and signs of the DCT spectral coefficients as the Absolute Spectrum (AS) and Polarity Spectrum (PoS), respectively.
Fickenscher, Thomas, Paliwal, Kuldip, Shi, Sisi, Busch, Andrew   +3 more
core   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Clinical Variability and Genotype Driven Outcomes in an International Cohort of 14 Pediatric FIG4 Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Biallelic FIG4 variants classically cause distinct conditions characterized by peripheral neuropathy (Charcot‐Marie‐Tooth disease type 4J) or skeletal dysplasia (Yunis‐Varón syndrome). However, central nervous system involvement is increasingly recognized. The prevalence and specific characteristics of movement disorders within FIG4‐
Andrea Gangfuß, Vykuntaraju K. Gowda, Daniel Natera‐de Benito, Pinki Munot, Maria Vanegas, Alejandra Darling, Constanze Reutlinger, Laura Carrera‐Garcia, Gilbert Wunderlich, Heike Kölbel, Burkhard Stüve, David Muhmann, Lucía Monfort Belenguer, Diana‐Gabriela Barca, Viveka Santhosh Reddy C, Varunvenkat M. Srinivasan, Cristina Molina Anguita, Heinz Jungbluth, Hormos Salimi Dafsari, Thomas Rossor, Johann Böhm, Ulrike Schara‐Schmidt, Andreas Roos   +22 more
wiley   +1 more source

Spectrum of the direct sum of operators

Electronic Journal of Differential Equations, 2012
We study the connection between spectral properties of direct the sum of operators in the direct sum of Hilbert spaces and its coordinate operators.
Elif Otkun Cevik, Zameddin I. Ismailov
doaj  

Spectrum of Discrete Second-Order Difference Operator with Sign-Changing Weight and Its Applications

Discrete Dynamics in Nature and Society, 2014
Let T>1 be an integer, and let𝕋=1,2,…,T. We discuss the spectrum of discrete linear second-order eigenvalue problems Δ2ut-1+λmtut=0, t∈𝕋,  u0=uT+1=0, where λ≠0 is a parameter, m:𝕋→ℝ changes sign and mt≠0 on 𝕋.
Ruyun Ma, Chenghua Gao
doaj   +1 more source

Wave Equation of Discrete Spectrum States Transition Processes

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2010
For the dynamic description of object quantum transition, function of space coordinates matrix elements and time (transition wave function) is determined. It plays the role for transition analogous, to wave function for state.
A. Yu. Samarin
doaj   +1 more source

Cerebrospinal Fluid GAD65‐Antibody Levels Accurately Identify Relevant Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Retrospective cohort study to investigate which factors most reliably distinguish incidental GAD65‐antibodies (iGAD65) from true GAD65‐antibody neurological disease (tGAD65). 167 adults with positive serum and CSF GAD65‐antibodies (> 0.02 nmol/L by radioimmunoassay) were classified as tGAD65 or iGAD65, with diagnostic performance of ...
Max Charles Herman, Maya Marzello, Zoaib Habib Tharwani, Snigdha Kotaru, Yoav D. Piura, Eric Newman, Gregory S. Day, Andrew McKeon, A. Sebastian Lopez‐Chiriboga, Sarosh R. Irani   +9 more
wiley   +1 more source

Spectral Analysis of Schrödinger Operators with Unusual Semiclassical Behavior

Acta Polytechnica, 2013
In this paper we discuss several examples of Schrödinger operators describing a particle confined to a region with thin cusp-shaped ‘channels’, given either by a potential or by a Dirichlet boundary; we focus on cases when the allowed phase space is ...
Pavel Exner, Diana Barseghyan
doaj