From Common Pathway to Divergent Diseases: Metabolic Aspects of Inborn Errors of CoA Biosynthesis
ABSTRACT Coenzyme A (CoA) biosynthesis is a conserved, dynamically regulated pathway essential for mitochondrial energy production, fatty acid oxidation, lipid biosynthesis and protein acylation. Biallelic variants in PANK2, PPCS, PPCDC, and COASY cause rare inborn errors of CoA biosynthesis, associated with markedly different clinical phenotypes ...
Ivano Di Meo +3 more
wiley +1 more source
What matters most to older adults in treatment decision making: A discrete choice experiment. [PDF]
Hanewinkel VC +8 more
europepmc +1 more source
Histiocytosis development and clinical variation through the lens of genomics
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
Bacterial clusters are associated with the risk of severe disease progression in inflammatory bowel disease irrespective of conventional disease categories. [PDF]
Hansen SH +19 more
europepmc +1 more source
AI and Big Data in Consumer Behavior Analysis. ABSTRACT The rapid expansion of digital consumer data has challenged traditional approaches to understanding behavior in digital marketing. Existing reviews often focus on individual methods and give limited guidance on how analytical techniques compare or how they should be selected for specific marketing
Leonidas Theodorakopoulos +1 more
wiley +1 more source
Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment. [PDF]
Bassil Y +5 more
europepmc +1 more source
Book Review: Discrete subgroups of semisimple Lie groups [PDF]
openaire +1 more source
Abstract Objectives Exercise‐induced affective responses (ARs) may encourage people with chronic diseases (PCD) to engage in future physical activity (PA). This study examined whether AR timing during exercise predicts daily moderate‐to‐vigorous PA (MVPA) in PCD and explored two mediating pathways: the reflective affect processing pathway (via ...
Layan Fessler +5 more
wiley +1 more source
Papillary Renal Neoplasm with Reversed Polarity in a 64-Year-Old Male: A Rare Case Report and Review of the Literature. [PDF]
Wang Y, Zhang M, Su G, Zhou Q.
europepmc +1 more source
ABSTRACT Aims To test the hypothesis that continuous glucose monitoring (CGM) metrics are independently associated with cardiovascular risk factor (CVRF) exposure, particularly low‐density lipoprotein cholesterol (LDL‐C) and blood pressure (BP), in youth with type 1 diabetes (T1D) enrolled in the international SWEET registry. Materials and Methods This
Claudia Piona +13 more
wiley +1 more source

