Results 41 to 50 of about 1,979,033 (284)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Integrable Systems and Discrete Geometry

, 2005
This is an expository article for Elsevier's Encyclopedia of Mathematical Physics on the subject in the title.
Akhmetshin, Bial̷ecki, Bobenko, Bogdanov, Cieśliński, Doliwa, Doliwa, Doliwa, Doliwa, Doliwa, Klimczewski, Matsuura, Mañas, Rogers, Schief, Schief   +15 more
core   +1 more source

An Approximate Method for Solving Optimal Control Problems for Discrete Systems Based on Local Approximation of an Attainability Set

Известия Иркутского государственного университета: Серия "Математика", 2017
An optimal control problem for discrete systems is considered. A method of successive improvements along with its modernization based on the expansion of the main structures of the core algorithm about the parameter is suggested.
V. A. Baturin
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Instability with growth rates of discrete systems in Banach spaces

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we investigate new forms of instability for linear discrete-time dynamical systems in Banach spaces, focusing on characterizations described by non-exponential growth rates.
Carmen-Florinela Popa
doaj   +1 more source

On a discretization of confocal quadrics. II. A geometric approach to general parametrizations

, 2017
We propose a discretization of classical confocal coordinates. It is based on a novel characterization thereof as factorizable orthogonal coordinate systems. Our geometric discretization leads to factorizable discrete nets with a novel discrete analog of
Bobenko, Alexander I., Schief, Wolfgang K., Suris, Yuri B., Techter, Jan   +3 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Discrete Memristive Hindmarsh-Rose Neural Model with Fractional-Order Differences

Fractal and Fractional
Discrete systems can offer advantages over continuous ones in certain contexts, particularly in terms of simplicity and reduced computational costs, though this may vary depending on the specific application and requirements.
Fatemeh Parastesh, Karthikeyan Rajagopal, Sajad Jafari, Matjaž Perc   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Darboux and binary Darboux transformations for discrete integrable systems 1. Discrete potential KdV equation

, 2013
The Hirota-Miwa equation can be written in `nonlinear' form in two ways: the discrete KP equation and, by using a compatible continuous variable, the discrete potential KP equation.
Nimmo, Jonathan J C, Shi, Ying, Zhang, Da-jun   +2 more
core   +1 more source