Results 41 to 50 of about 29,522 (302)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Generalized Running Discrete Transforms

, 1982
This Paper Introduces a Generalized Running Discrete Transform with Respect to Arbitrary Transform Basea, and Relates the Generalized Transform to the Running Discrete Fourier Z and Short-Time Discrete Fourier Transforms.
Stuller, John A.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Development of a Very Low-Cost Deforestation Monitoring System Based on Aerial Image Clustering and Compression Techniques

Advances in Electrical and Computer Engineering
Clustering holds significant utility across a spectrum of several domains, including pattern recognition, image analysis, customer analytics, market segmentation, social network analysis, and numerous other areas. The main advantages of image clustering
ANDREI, A.-T., GRIGORE, O.
doaj   +1 more source

Classification of Resampled Pediatric Epilepsy EEG Data Using Artificial Neural Networks with Discrete Fourier Transforms

Elektronika ir Elektrotechnika, 2023
Epilepsy is a neurological disorder commonly observed in children. Currently, electroencephalography (EEG) is widely used as the most important diagnostic method for epilepsy in medical practice.
Temel Sonmezocak, Gizem Guler, Merih Yildiz   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Two-Dimensional Discrete Coupled Fractional Fourier Transform (DCFrFT)

Fractal and Fractional
The fractional Fourier transform is critical in signal processing and supports many applications. Signal processing is one notable application. Implementing the fractional Fourier transform requires discrete versions.
Asma Elshamy, Zeinab S. I. Mansour, Ahmed Zayed   +2 more
doaj   +1 more source

Medical Image Retrieval Using Transforms [PDF]

Applied Medical Informatics, 2013
The purpose of this study is to access the stability of transformation methods for medical image analysis. The reason for image retrieval is due to the increase in acquisition of images.
Mannivannan VASUKI, Swarnambiga AYYACHAMY   +1 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source