Results 41 to 50 of about 3,552,646 (301)

Discrete Lorentz covariance for quantum walks and quantum cellular automata

New Journal of Physics, 2014
We formalize a notion of discrete Lorentz transforms for quantum walks (QW) and quantum cellular automata (QCA), in $(1+1)$ -dimensional discrete spacetime.
Pablo Arrighi, Stefano Facchini, Marcelo Forets   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Classification of Resampled Pediatric Epilepsy EEG Data Using Artificial Neural Networks with Discrete Fourier Transforms

Elektronika ir Elektrotechnika, 2023
Epilepsy is a neurological disorder commonly observed in children. Currently, electroencephalography (EEG) is widely used as the most important diagnostic method for epilepsy in medical practice.
Temel Sonmezocak, Gizem Guler, Merih Yildiz   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Two-Dimensional Discrete Coupled Fractional Fourier Transform (DCFrFT)

Fractal and Fractional
The fractional Fourier transform is critical in signal processing and supports many applications. Signal processing is one notable application. Implementing the fractional Fourier transform requires discrete versions.
Asma Elshamy, Zeinab S. I. Mansour, Ahmed Zayed   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Medical Image Retrieval Using Transforms [PDF]

Applied Medical Informatics, 2013
The purpose of this study is to access the stability of transformation methods for medical image analysis. The reason for image retrieval is due to the increase in acquisition of images.
Mannivannan VASUKI, Swarnambiga AYYACHAMY   +1 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Systolic implementation of real-valued discrete transforms via algebraic integer quantization

, 2001
In this paper, we propose a novel approach for computing real-valued discrete transforms such as the discrete cosine transform (DCT) and the discrete Hartley transform (DHT). The approach is based on the algebraic integer encoding scheme. With the aid of
R. Baghaie, V. Dimitrov
semanticscholar   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source