Results 111 to 120 of about 15,012 (296)

Current evidence and insights on single vs. double dose of basiliximab in adult solid organ transplant recipients: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this systematic review was to assess all available clinical data regarding the use of a single dose of basiliximab in solid organ transplantation compared to the standard double dosage, with particular interest in efficacy, safety and cost‐savings.
Alessio Provenzani, Braidon A. Lape, Anneliese M. Harp, Victoria Weisbrod, Lavinia Piazza   +4 more
wiley   +1 more source

A DEA–based efficiency evaluation method for metro-led urban underground public space

Underground Space
Despite the thriving development of metro-led urban underground public space (UUPS) and its significant benefits and costs, there remains a critical research gap in understanding and evaluating its efficiency.
Zi-Yun Zhang, Fang-Le Peng, Chen-Xiao Ma, Yong-Kang Qiao   +3 more
doaj   +1 more source

Discretionary decision-making in the probation supervision setting: Empirical measurement of the influence of legal, socioeconomic, supervision and risk-assessment factors

, 1989
This research draws on the labelling theorist\u27s perspective in criminology and empirically measures significant factors that influence discretionary decision-making in the adult, probation supervision setting.
Golbin, James John
core  

‘I need to talk to Sarge’: The role of sergeants in discretionary decision-making [PDF]

Police discretion has become a popular concept in policing literature despite its ambiguous and amorphous nature. Discretion is often rationalised as a necessary and inevitable part of everyday policing and distinctive occupational cultures are seen as ...
Molyneux, Leah
core   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Discretionary Decision in the Croatian and European Laws: Control and Compensation

, 2010
Opisuje se institut slobodne (diskrecijske) ocjene u hrvatskome i europskom pravu, s posebnim naglaskom na kontrolu akata koji sadržavaju diskrecijsku (slobodnu) ocjenu i na naknadu štete u hrvatskome upravnom pravu i europskom pravu.
Osrečak, Jadranka, Jadranka Osrečak
core  

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

How Discretionary Decision-Making Impacts the Financial Performance and Legal Disclosures of S&P 500 Funds

, 2022
When investment funds track the S&P 500, the index becomes more than just a list of 500 companies. The focus then becomes the financial and regulatory issues that arise from the discretionary decision-making power of the Index Committee that governs the ...
Deluard, Vincent, Sharfman, Bernard S.
core  

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source