Results 21 to 30 of about 943 (248)

Universal convex covering problems under translations and discrete rotations

open access: yesAdvances in Geometry, 2023
Abstract We consider the smallest-area universal covering of planar objects of perimeter 2 (or equivalently, closed curves of length 2) allowing translations and discrete rotations. In particular, we show that the solution is an equilateral triangle of height 1 when translations and discrete rotations of π are allowed.
Mook Kwon Jung   +3 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Discrete Structural Planning for Neural Machine Translation

open access: yesCoRR, 2018
Structural planning is important for producing long sentences, which is a missing part in current language generation models. In this work, we add a planning phase in neural machine translation to control the coarse structure of output sentences. The model first generates some planner codes, then predicts real output words conditioned on them.
Raphael Shu, Hideki Nakayama
openaire   +2 more sources

A new version fast multipole method for evaluating the stress field of dislocation ensembles

open access: yes, 2010
Dislocations are the primary carriers of plastic deformation in crystals. Dislocation dynamics simulation is becoming an important tool for the study of plastic behaviors of crystalline materials.
Zhao, Degang   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Garside groups are strongly translation discrete

open access: yesJournal of Algebra, 2007
The Garside group, as a generalization of braid groups and Artin groups of finite types, is defined as the group of fractions of a Garside monoid. We show that the semidirect product of Garside monoids is a Garside monoid. We use the semidirect product $\mathbb Z\ltimes G^n$ of the infinite cyclic group $\mathbb Z$ and the cartesian product $G^n$ of a ...
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

On the Translation Parameter Problem for Discrete Variables

open access: yesThe Annals of Mathematical Statistics, 1951
For any chance variable $x = (x_1,\cdots,x_N)$ having known distribution, the translation parameter estimation problem is to estimate an unknown constant $h$, having observed $y = (x_1 + h,\cdots,x_N + h)$. Extending the work of Pitman [2], Girshick and Savage [1] have, for any loss function depending only on the error of estimate, described an ...
openaire   +2 more sources

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