Results 81 to 90 of about 584,742 (263)
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Low-Rank Kernel-Based Semisupervised Discriminant Analysis
Applied Computational Intelligence and Soft Computing, 2016 Semisupervised Discriminant Analysis (SDA) aims at dimensionality reduction with both limited labeled data and copious unlabeled data, but it may fail to discover the intrinsic geometry structure when the data manifold is highly nonlinear.
Baokai Zu +3 more
doaj +1 more source
Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source
Singularities of Discriminant Loci of Laurent Polynomial Systems
Известия Иркутского государственного университета: Серия "Математика"We consider a system of n Laurent polynomials in n unknowns with variable complex coefficients. For the reduced discriminant locus of such a system, we study the set of critical points of the Horn–Kapranov parametrization.
I.A. Antipova, S. Yu. Chuvashov
doaj +1 more source
Zygon: Journal of Religion and Science, 1982 Sooner or later discussions of population problems raise the issue of altruism. Why should I refrain from exploiting the environment because posterity may some day wish that I had? Or because today's poor want a larger share of the world's wealth? Is altruism natural? Is it safe?
openaire +1 more source
Advanced Science, EarlyView.ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo +13 more
wiley +1 more source
DISCRIMINANT STEPWISE PROCEDURE
Acta Universitatis Lodziensis. Folia Oeconomica, 2014 Stepwise procedure is now probably the most popular tool for automatic feature selection. In the most cases it represents model selection approach which evaluates various feature subsets (so called wrapper). In fact it is heuristic search technique which
Mariusz Kubus
doaj
Advanced Science, EarlyView.This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv +12 more
wiley +1 more source
E-Jurnal Matematika, 2017 Tabanan Regency is one of the eight regencies and one municipality in Bali Province. Administratively, it is divided into 10 districs and villages. There are rural areas and urban areas in the regions. Discriminant analysis is a technique related to the
IDA AYU MADE SUPARTINI +2 more
doaj +1 more source
Low-dimensional Singularities with Free Divisors as Discriminants
, 2006 We present versal complex analytic families, over a smooth base and of fibre dimension zero, one, or two, where the discriminant constitutes a free divisor.
Bothmer, Hans-Christian Graf v. +2 more
core