Results 41 to 50 of about 972,224 (309)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Ideological attitudes predicting online hate speech: the differential effects of right-wing authoritarianism and social dominance orientation

Frontiers in Social Psychology
IntroductionWhile research on online hate speech (OHS) has expanded in recent years, only few studies adopt a theoretical framework to understand how ideological attitudes differentially motivate individuals to engage with OHS.
Laura Dellagiacoma, Laura Dellagiacoma, Daniel Geschke, Tobias Rothmund   +3 more
doaj   +1 more source

The Roma in Turkiye: Segregation in The Labour Market and Income Differentiations

Journal of Economy Culture and Society, 2022
In labour market research, rather than demographic and human capital endowments, ethnicity is considered a major explanatory of segregation in job occupations.
Sinem Bağçe
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Association and Predictive Ability of ECG Abnormalities with Cardiovascular Diseases: A Prospective Analysis

Global Heart, 2020
Aims: To examine whether electrocardiography (ECG) could provide additional values to the traditional risk factors for cardiovascular disease (CVD) risk prediction among different cardiovascular risk subgroups.
Jingya Niu, Chanjuan Deng, Ruizhi Zheng, Min Xu, Jieli Lu, Tiange Wang, Zhiyun Zhao, Yuhong Chen, Shuangyuan Wang, Meng Dai, Yu Xu, Weiqing Wang, Guang Ning, Yufang Bi, Mian Li   +14 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bounded Solidarity in Cross-National Encounters: Individuals Share More with Others from Poor Countries but Trust Them Less

Sociological Science, 2020
Globalization makes cross-national encounters increasingly common. Hesitant cooperation across national, ethnic, and cultural boundaries, however, undercuts the microlevel stabilizers of global integration and, most importantly, the willingness to share ...
Felix Bader, Marc Keuschnigg
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Non-Discrimination in Turkey

, 2022
The book “Non-discrimination in Turkey” focuses on issue areas within the broader non-discrimination framework in Turkey. It looks domestic change in Turkey regarding non-discrimination across time.
Yilmaz,G.
core   +1 more source