Results 41 to 50 of about 1,247,617 (308)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Bounded Solidarity in Cross-National Encounters: Individuals Share More with Others from Poor Countries but Trust Them Less

Sociological Science, 2020
Globalization makes cross-national encounters increasingly common. Hesitant cooperation across national, ethnic, and cultural boundaries, however, undercuts the microlevel stabilizers of global integration and, most importantly, the willingness to share ...
Felix Bader, Marc Keuschnigg
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Discrimination of artificial intelligence in healthcare

Digital Diagnostics, 2023
Currently, artificial intelligence (AI) plays an important role in various fields as a primary worker or assistant, especially in healthcare. AI has many functions that can be performed even better than humans do due to the high speed of compiling a ...
Michael Yu. Khomyakov
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

“The Best Times of Our Lives?” Institutional Factors That Shape University Students’ Quality of Life

SAGE Open
Acquiring a thorough grasp of the factors influencing students’ academic quality of life is essential for educators, administrators, and legislators to successfully support students and foster an environment centered on their well-being and growth ...
Atalia Oniţiu, Elena-Loreni Baciu, Theofild-Andrei Lazăr, Roxana Ungureanu, Loredana-Marcela Trancă, Norberth-Ioan Okros   +5 more
doaj   +1 more source

Evaluating student evaluations: evidence of gender bias against women in higher education based on perceived learning and instructor personality

Frontiers in Education, 2023
Given student evaluations are an integral part of academic employment and progression in higher education, it is crucial to explore various biases amongst students that may influence their ratings.
Olga Khokhlova, Nishtha Lamba, Sameer Kishore   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Racism in German healthcare: uncovering the construction and silencing of the “other”

Frontiers in Public Health
While the impact of racism on healthcare interactions has been researched extensively in many parts of the world, substantive studies on healthcare-related racism in Europe, and particularly in Germany, remain scarce.
Tanja Gangarova, Melike Yildiz, Lina Kabangu   +2 more
doaj   +1 more source