Results 61 to 70 of about 1,160,952 (340)

Mixed discriminants

Mathematische Zeitschrift, 2012
The mixed discriminant of n Laurent polynomials in n variables is the irreducible polynomial in the coefficients which vanishes whenever two of the roots coincide. The Cayley trick expresses the mixed discriminant as an A-discriminant. We show that the degree of the mixed discriminant is a piecewise linear function in the Plucker coordinates of a mixed
Cattani, Eduardo, Cueto, Maria Angelica, Dickenstein, Alicia, Rocco, Sandra Di, Strumfels, Bernd   +4 more
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

FROM THE NATIONAL COUNCIL FOR COMBATING DISCRIMINATION TO THE COURT OF JUSTICE OF EUROPEAN UNION – CASE C-81/12 [PDF]

Challenges of the Knowledge Society, 2013
The scope of this research is to present and analyze national and European, jurisdictional-administrative procedural issues, if courts are notified related to certain discriminatory statements.
CRISTIAN JURA
doaj  

The Hessian Discriminant

Le Matematiche, 2019
We express the Hessian discriminant of a cubic surface in terms of fundamental invariants. This answers Question 15 from the \emph{27 questions on the cubic surface}. We also explain how to compute the fundamental invariants for smooth cubics of rank 6.
Dinu, Rodica, Seynnaeve, Tim
openaire   +4 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Integrating Growth and Environmental Parameters to Discriminate Powdery Mildew and Aphid of Winter Wheat Using Bi-Temporal Landsat-8 Imagery

Remote Sensing, 2019
Monitoring and discriminating co-epidemic diseases and pests at regional scales are of practical importance in guiding differential treatment. A combination of vegetation and environmental parameters could improve the accuracy for discriminating crop ...
Huiqin Ma, Wenjiang Huang, Yuanshu Jing, Chenghai Yang, Liangxiu Han, Yingying Dong, Huichun Ye, Yue Shi, Qiong Zheng, Linyi Liu, Chao Ruan   +10 more
doaj   +1 more source

Consumer-Lending Discrimination in the Fintech Era

Journal of Financial Economics, 2017
U.S. fair-lending law prohibits lenders from making credit determinations that disparately affect minority borrowers if those determinations are based on characteristics unrelated to creditworthiness. Using an identification under this rule, we show risk-
Robert P. Bartlett, Adair Morse, Richard Stanton, N. Wallace   +3 more
semanticscholar   +1 more source

Patient-Reported Experiences of Discrimination in the US Health Care System

JAMA Network Open, 2020
Key Points Question What are the national prevalence, frequency, and main types of discrimination that adult patients report experiencing in the US health care system?
Paige Nong, Minakshi Raj, Melissa S. Creary, Sharon L. R. Kardia, Jodyn E. Platt   +4 more
semanticscholar   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source