Results 61 to 70 of about 1,172,950 (315)
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Discrimination in the Venture Capital Industry: Evidence from Field Experiments [PDF]
arXiv, 2020 This paper examines discrimination by early-stage investors based on startup founders' gender and race using two complementary field experiments with real U.S. venture capitalists. Results show the following. (i) Discrimination varies depending on the context.
arxiv
Programmable quantum state discriminator by Nuclear Magnetic Resonance [PDF]
Phys. Rev. A 71, 042307 (2005), 2005 In this paper a programmable quantum state discriminator is implemented by using nuclear magnetic resonance. We use a two qubit spin-1/2 system, one for the data qubit and one for the ancilla (programme) qubit. This device does the unambiguous (error free) discrimination of pair of states of the data qubit that are symmetrically located about a fixed ...
arxiv +1 more source
Racism in German healthcare: uncovering the construction and silencing of the “other”
Frontiers in Public HealthWhile the impact of racism on healthcare interactions has been researched extensively in many parts of the world, substantive studies on healthcare-related racism in Europe, and particularly in Germany, remain scarce.
Tanja Gangarova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Racial/ethnic discrimination and health: findings from community studies.
American Journal of Public Health, 2003 The authors review the available empirical evidence from population-based studies of the association between perceptions of racial/ethnic discrimination and health.
David R. Williams +2 more
semanticscholar +1 more source
Sociological Perspectives on Racial Discrimination
Journal of Economic Perspectives, 2020 As in economics, racial discrimination has long been a focus of research in sociology. Yet the disciplines traditionally have differed in how they approach the topic. While some studies in recent years show signs of cross-disciplinary influence, exposing
M. Small, D. Pager
semanticscholar +1 more source
Aleatoric and Epistemic Discrimination: Fundamental Limits of Fairness Interventions [PDF]
arXiv, 2023 Machine learning (ML) models can underperform on certain population groups due to choices made during model development and bias inherent in the data. We categorize sources of discrimination in the ML pipeline into two classes: aleatoric discrimination, which is inherent in the data distribution, and epistemic discrimination, which is due to decisions ...
arxiv
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source