Results 121 to 130 of about 11,523,117 (237)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
, 2015 The purpose of this note is to promote a discussion at IFPRI on impact evaluation. It discusses the benefits and problems of impact evaluation, presents several different concepts for evaluating impact, and then applies these to the five stages of IFPRI ...
http://orcid.org/0000-0002-0112-502X Ahmed, A.; http://orcid.org/0000-0002-1077-921X Islam, Yassir +1 more
core
Reflections on Hegemonies of Knowledge Production and the Politics of Disciplinary Divisions
, 2016 This article is part of the TRAFO Series “Provincializing Epistemologies”. by Ruth Streicher and Schirin Amir-Moazami Introduction “Provincializing Epistemologies” is a discussion series that aims to politicize contemporary forms of knowledge production ...
trafo discussion
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Analytical discussion of directionals, part 2
, 2016 Recording of a discussion on directionals at the 2016 Orthography Workshop at Don Bosco ...
Basumatary, Prafulla
core
ConnectionsOne model to foster institutional change and promote college student success is the Departmental Action Team (DAT) framework, which deploys a small discussion group of departmental faculty, staff, and students to identify challenges and implement ...
Han Jaeyun +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source