Results 161 to 170 of about 19,607,477 (309)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Idiosyncratic Risk, Market Risk and Correlation Dynamics in European Equity Markets [PDF]
We examine total, market and idiosyncratic risk and correlation dynamics using daily data from 1993 to 2001 on the 6 largest euro-zone stock market indices and 42 firms from the Dow Jones Eurostoxx50 index. We also estimate conditional correlations using
Colm Kearney, Valerio Poti
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Anti-Foundationalism, Deliberative Democracy, and Universal Human Rights [PDF]
Classification-
Eunan O' Halpin
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A Framework for Supporting Patients and Families After a Severe Maternal Event. [PDF]
Obstet GynecolBauer ME +9 more
europepmc +1 more source
Individualization and Equality:Women’s careers and organizational form [PDF]
Some feminist writings have claimed that ‘bureaucracy’ is inherently ‘patriarchal’. This paper challenges this argument by comparing the experience of women in Ireland in a state sector organization and in a cluster of software firms.
Deirdre Crowe +3 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Fourth Credit Hour: How do we Teach in Biology Discussion Sections? [PDF]
CBE Life Sci EducMueller LO +6 more
europepmc +1 more source