Results 171 to 180 of about 4,917,328 (270)

Large Language Model-Based Analysis of Statin Therapy Discussions and Sentiment on Social Media: Cross-Sectional Observational Study.

J Med Internet Res
Liu S, Liu J.
europepmc   +1 more source

Beyond the emergency: Centering mental health in community disaster preparedness and recovery. [PDF]

PLoS One
Adepoju OE, Smith AM, de la Roche LA, Curtis D.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Co-Design of strategies to enhance access to Virtual Urgent Care models by equity-deserving populations. [PDF]

PLOS Digit Health
Hitzig SL, Ahmed YHE, Alamgir A, Kupka CF, Ledwos C, Sothilingam R, Alitawi R, Motsenok M, Orr J, Reis L, Siqueira I, Sivakumaran S, Brush T, Devotta K, Haseeb MK, Huynh E, Jalil E, Khorasheh T, Ky K, McLeod SL, MacLellan W, Mills S, Pilested K, Rosenstein D, Sheppard CL, Stothers S, Zhang J, Yoon R, Zhang C, Mehta S, Najeeb U, Hall JN.   +31 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Engaging in a dialogue with the Luton Roma community on access to healthcare services and co-producing solutions. [PDF]

Front Public Health
Ali N, Vincent BP, Akenbor O, Mackay F, Cook E, Morteanu C, Randhawa G.   +6 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Internalized stigma, negative affect, and intimate partner violence perpetration among sexual minority couples. [PDF]

J Fam Psychol
Sullivan TJ, O'Leary KD, Davila J.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Enhancing Team-Based Learning in Virtual Environments: The Role of Avatar Agency and Immersive Social Presence.

JMIR Med Educ
Funao H, Shimaoka M, Kako J.
europepmc   +1 more source