Results 181 to 190 of about 4,917,328 (270)

Mnemonic of Principles for Effective Specialist-Generalist Conferences: The BRIDGE. [PDF]

J Gen Fam Med
Kanzawa Y, Tetsuou Tsukada Y, Ishibashi K, Ono M, Matsushima Y, Shingu M, Saito H, Tamita K, Ishimaru N.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Moderators' Role in Fostering Health Practitioner Engagement Within an Online Active Learning Program (The Community Fracture Capture Learning Hub): Qualitative Relational Content Thematic Analysis.

J Med Internet Res
Fathalla AM, Chang S, Audehm R, Chiang C, Gorelik A, Yates CJ, Snow S, Barmanray RD, Price S, Collins L, Wark JD.   +10 more
europepmc   +1 more source

Scaling the RNA Summit: Reflections on the 2026 OPT congress. [PDF]

Mol Ther Nucleic Acids
Giangrande PH.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Teens' Time Alone with Their Clinician: Receipt of Health Care Transition Preparation and Anticipatory Guidance. [PDF]

J Am Board Fam Med
Black LI, Ng AE, Zablotsky B, Bose J, Jones JR, Blumberg SJ.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Discussions about climate change [PDF]

Anais da Academia Brasileira de Ciências
ALEXANDER W.A. KELLNER
doaj   +1 more source

Antimicrobial redistribution: health practitioner One health perspectives on antimicrobial use in livestock for antimicrobial resistance education in Zimbabwe. [PDF]

JAC Antimicrob Resist
Mickelsson M, Simbini T.
europepmc   +1 more source

Research-teaching linkages : enhancing graduate attributes. Vol. 1, Sector-wide discussions [PDF]

, 2008
Gordon, George, Land, Ray
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